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OpenCell :
OpenCell : Endogenous tagging for the cartography of human cellular organization
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- Cho, Nathan H. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Cheveralls, Keith C. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Brunner, Andreas-David (author)
- Max Planck Inst Biochem, Prote & Signal Transduct, Martinsried, Germany.
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- Kim, Kibeom (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Michaelis, Andre C. (author)
- Max Planck Inst Biochem, Prote & Signal Transduct, Martinsried, Germany.
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- Raghavan, Preethi (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Kobayashi, Hirofumi (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Savy, Laura (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Li, Jason Y. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Canaj, Hera (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Kim, James Y. S. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Stewart, Edna M. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Gnann, Christian (author)
- KTH,Science for Life Laboratory, SciLifeLab,Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- McCarthy, Frank (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Cabrera, Joana P. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Brunetti, Rachel M. (author)
- Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA USA.
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- Chhun, Bryant B. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Dingle, Greg (author)
- Chan Zuckerberg Initiat, Redwood City, CA USA.
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- Hein, Marco Y. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Huang, Bo (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.;Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA USA.;Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA USA.
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- Mehta, Shalin B. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Weissman, Jonathan S. (author)
- Howard Hughes Med Inst, Whitehead Inst, Koch Inst, Cambridge, MA USA.;MIT, Dept Biol, Cambridge, MA USA.;Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA USA.
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- Gomez-Sjoberg, Rafael (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Itzhak, Daniel N. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Royer, Loic A. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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- Mann, Matthias (author)
- Max Planck Inst Biochem, Prote & Signal Transduct, Martinsried, Germany.;Univ Copenhagen, Fac Hlth & Med Sci, NNF Ctr Prot Res, Copenhagen, Denmark.
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- Leonetti, Manuel D. (author)
- Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
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Chan Zuckerberg Biohub, San Francisco, CA 94158 USA Max Planck Inst Biochem, Prote & Signal Transduct, Martinsried, Germany. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2022
- 2022
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375:6585, s. 1143-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates functional communities that facilitate biological discovery. We found that remarkably precise functional information can be derived from protein localization patterns, which often contain enough information to identify molecular interactions, and that RNA binding proteins form a specific subgroup defined by unique interaction and localization properties. Paired with a fully interactive website (opencell.czbiohub.org), our work constitutes a resource for the quantitative cartography of human cellular organization.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Science
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- By the author/editor
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Cho, Nathan H.
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Cheveralls, Keit ...
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Brunner, Andreas ...
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Kim, Kibeom
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Michaelis, Andre ...
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Raghavan, Preeth ...
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show more...
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Kobayashi, Hirof ...
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Savy, Laura
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Li, Jason Y.
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Canaj, Hera
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Kim, James Y. S.
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Stewart, Edna M.
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Gnann, Christian
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McCarthy, Frank
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Cabrera, Joana P ...
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Brunetti, Rachel ...
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Chhun, Bryant B.
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Dingle, Greg
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Hein, Marco Y.
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Huang, Bo
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Mehta, Shalin B.
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Weissman, Jonath ...
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Gomez-Sjoberg, R ...
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Itzhak, Daniel N ...
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Royer, Loic A.
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Mann, Matthias
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Leonetti, Manuel ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Science
- By the university
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Royal Institute of Technology