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Search: WFRF:(Cho Nathan H.) > OpenCell :

  • Cho, Nathan H.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)

OpenCell : Endogenous tagging for the cartography of human cellular organization

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-310769
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-310769URI
  • https://doi.org/10.1126/science.abi6983DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20220407
  • Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates functional communities that facilitate biological discovery. We found that remarkably precise functional information can be derived from protein localization patterns, which often contain enough information to identify molecular interactions, and that RNA binding proteins form a specific subgroup defined by unique interaction and localization properties. Paired with a fully interactive website (opencell.czbiohub.org), our work constitutes a resource for the quantitative cartography of human cellular organization.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Cheveralls, Keith C.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Brunner, Andreas-DavidMax Planck Inst Biochem, Prote & Signal Transduct, Martinsried, Germany. (author)
  • Kim, KibeomChan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Michaelis, Andre C.Max Planck Inst Biochem, Prote & Signal Transduct, Martinsried, Germany. (author)
  • Raghavan, PreethiChan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Kobayashi, HirofumiChan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Savy, LauraChan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Li, Jason Y.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Canaj, HeraChan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Kim, James Y. S.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Stewart, Edna M.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Gnann, ChristianKTH,Science for Life Laboratory, SciLifeLab,Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.(Swepub:kth)u1338pp0 (author)
  • McCarthy, FrankChan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Cabrera, Joana P.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Brunetti, Rachel M.Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA USA. (author)
  • Chhun, Bryant B.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Dingle, GregChan Zuckerberg Initiat, Redwood City, CA USA. (author)
  • Hein, Marco Y.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Huang, BoChan Zuckerberg Biohub, San Francisco, CA 94158 USA.;Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA USA.;Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA USA. (author)
  • Mehta, Shalin B.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Weissman, Jonathan S.Howard Hughes Med Inst, Whitehead Inst, Koch Inst, Cambridge, MA USA.;MIT, Dept Biol, Cambridge, MA USA.;Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA USA. (author)
  • Gomez-Sjoberg, RafaelChan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Itzhak, Daniel N.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Royer, Loic A.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Mann, MatthiasMax Planck Inst Biochem, Prote & Signal Transduct, Martinsried, Germany.;Univ Copenhagen, Fac Hlth & Med Sci, NNF Ctr Prot Res, Copenhagen, Denmark. (author)
  • Leonetti, Manuel D.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA. (author)
  • Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.Max Planck Inst Biochem, Prote & Signal Transduct, Martinsried, Germany. (creator_code:org_t)

Related titles

  • In:Science: American Association for the Advancement of Science (AAAS)375:6585, s. 1143-+0036-80751095-9203

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