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In Vivo Versus In V...
In Vivo Versus In Vitro Degradation of a 3D Printed Resorbable Device for Ligation of Vascular Tissue in Horses
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- Adolfsson, Karin H. (author)
- KTH,Polymerteknologi
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- Sjöberg, I. (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Höglund, Odd (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Wattle, Ove (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Hakkarainen, Minna (author)
- KTH,Polymerteknologi
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(creator_code:org_t)
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- 2021-08-02
- 2021
- English.
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In: Macromolecular Bioscience. - : Wiley. - 1616-5187 .- 1616-5195. ; 21:10
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https://doi.org/10.1...
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Abstract
Subject headings
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- A resorbable 3D printed polydioxanone (PDO) device is manufactured to facilitate ligation of vascular tissue during surgery. The device must provide sufficient mechanical performance throughout the healing period. Therefore, degradation and mechanical performance of the device are investigated as a function of in vivo and in vitro aging. During aging the PDO device released cyclic and linear water-soluble products. In vivo aging resulted in higher relative number of linear oligomers in comparison to in vitro aging. A major loss of mechanical performance is observed after only 10 days in vivo and the Young’s modulus (E) and tensile strength at break (σb) decreased by 28% and 54%, respectively. This is in contrast to in vitro aging, where no loss of mechanical properties is observed during the same period. The in vivo aged devices exhibit clear holes in the matrices after 28 days, while apparent cracks are observed first after 140 days in vitro. These results highlight the sensitivity of the degradation process of resorbable devices with regards to the interactions of the device with the surrounding environment (tissues) and demonstrate the importance of in vivo testing as compliment to in vitro testing before clinical use of devices.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- 3D printing
- biomedical materials
- degradation products
- polydioxanone
- resorbable device
- Biodegradation
- Biomechanics
- Tensile strength
- Tissue
- Clinical use
- Degradation process
- In-vitro testing
- Linear oligomers
- Mechanical performance
- Surrounding environment
- Vascular tissue
- 3D printers
- meloxicam
- mepivacaine
- oligomer
- reactive oxygen metabolite
- Ringer lactate solution
- aging
- anatomical location
- anesthetic recovery
- animal experiment
- Article
- comparative study
- controlled study
- degradation
- environment
- field emission scanning electron microscopy
- general anesthesia
- glass transition temperature
- horse
- in vitro study
- in vivo study
- instrument sterilization
- introspection
- ligation
- local anesthesia
- mechanical test
- mechanics
- melting temperature
- nonhuman
- room temperature
- scanning electron microscopy
- skin incision
- three dimensional printing
- Young modulus
Publication and Content Type
- ref (subject category)
- art (subject category)
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