The Presence of the Temporal Horn Exacerbates the Vulnerability of Hippocampus During Head Impacts

Zhou, Zhou,1990-KTH,Neuronik,Department of Bioengineering, Stanford University, Stanford, CA, United States (author)

QC 20220421
Hippocampal injury is common in traumatic brain injury (TBI) patients, but the underlying pathogenesis remains elusive. In this study, we hypothesize that the presence of the adjacent fluid-containing temporal horn exacerbates the biomechanical vulnerability of the hippocampus. Two finite element models of the human head were used to investigate this hypothesis, one with and one without the temporal horn, and both including a detailed hippocampal subfield delineation. A fluid-structure interaction coupling approach was used to simulate the brain-ventricle interface, in which the intraventricular cerebrospinal fluid was represented by an arbitrary Lagrangian-Eulerian multi-material formation to account for its fluid behavior. By comparing the response of these two models under identical loadings, the model that included the temporal horn predicted increased magnitudes of strain and strain rate in the hippocampus with respect to its counterpart without the temporal horn. This specifically affected cornu ammonis (CA) 1 (CA1), CA2/3, hippocampal tail, subiculum, and the adjacent amygdala and ventral diencephalon. These computational results suggest that the presence of the temporal horn exacerbate the vulnerability of the hippocampus, highlighting the mechanobiological dependency of the hippocampus on the temporal horn.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
hippocampal injury
temporal horn
brain-ventricle interface
fluid-structure interaction
finite element analysis
traumatic brain injury

Li, XiaogaiKTH,Neuronik(Swepub:kth)u17pm33h (author)
Domel, August G.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA. (author)
Dennis, Emily L.Univ Utah, TBI & Concuss Ctr, Dept Neurol, Salt Lake City, UT USA.;Stanford Univ, Dept Radiol, Stanford, CA 94305 USA. (author)
Georgiadis, MariosStanford Univ, Dept Radiol, Stanford, CA 94305 USA. (author)
Liu, YuzheStanford Univ, Dept Bioengn, Stanford, CA 94305 USA. (author)
Raymond, Samuel J.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA. (author)
Grant, GeraldStanford Univ, Dept Neurosurg, Stanford, CA USA.;Stanford Univ, Dept Neurol, Stanford, CA USA. (author)
Kleiven, Svein,1966-KTH,Neuronik(Swepub:kth)u1aqbjml (author)
Camarillo, DavidStanford Univ, Dept Bioengn, Stanford, CA 94305 USA.;Stanford Univ, Dept Neurosurg, Stanford, CA USA.;Stanford Univ, Dept Mech Engn, Stanford, CA USA. (author)
Zeineh, MichaelStanford Univ, Dept Radiol, Stanford, CA 94305 USA. (author)
KTHNeuronik (creator_code:org_t)

By the author/editor: Zhou, Zhou, 1990 ...; Li, Xiaogai; Domel, August G.; Dennis, Emily L.; Georgiadis, Mari ...; Liu, Yuzhe; show more...; Raymond, Samuel ...; Grant, Gerald; Kleiven, Svein, ...; Camarillo, David; Zeineh, Michael; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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