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  • Blixt, L.Karolinska Institutet (author)

Covid-19 in patients with chronic lymphocytic leukemia : clinical outcome and B- and T-cell immunity during 13 months in consecutive patients

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-09-25
  • Springer Nature,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-311786
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-311786URI
  • https://doi.org/10.1038/s41375-021-01424-wDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147727919URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20220504
  • We studied clinical and immunological outcome of Covid-19 in consecutive CLL patients from a well-defined area during month 1–13 of the pandemic. Sixty patients (median age 71 y, range 43–97) were identified. Median CIRS was eight (4–20). Patients had indolent CLL (n = 38), had completed (n = 12) or ongoing therapy (n = 10). Forty-six patients (77%) were hospitalized due to severe Covid-19 and 11 were admitted to ICU. Severe Covid-19 was equally distributed across subgroups irrespective of age, gender, BMI, CLL status except CIRS (p < 0.05). Fourteen patients (23%) died; age ≥75 y was the only significant risk factor (p < 0.05, multivariate analysis with limited power). Comparing month 1–6 vs 7–13 of the pandemic, deaths were numerically reduced from 32% to 18%, ICU admission from 37% to 15% whereas hospitalizations remained frequent (86% vs 71%). Seroconversion occurred in 33/40 patients (82%) and anti-SARS-CoV-2 antibodies were detectable at six and 12 months in 17/22 and 8/11 patients, respectively. Most (13/17) had neutralizing antibodies and 19/28 had antibodies in saliva. SARS-CoV-2-specific T-cells (ELISpot) were detected in 14/17 patients. Covid-19 continued to result in high admission even among consecutive and young early- stage CLL patients. A robust and durable B and/or T cell immunity was observed in most convalescents.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bogdanovic, G. (author)
  • Buggert, M.Karolinska Institutet (author)
  • Gao, Y.Karolinska Institutet (author)
  • Hober, Sophia,Professor,1965-KTH,Science for Life Laboratory, SciLifeLab,Proteinteknologi(Swepub:kth)u11qqzc1 (author)
  • Healy, K. (author)
  • Johansson, H.Karolinska Institutet (author)
  • Kjellander, C.Karolinska Institutet (author)
  • Mravinacová, SáraKarolinska Institutet,KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1utu00u (author)
  • Muschiol, S.Karolinska Institutet (author)
  • Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1ws88sk (author)
  • Palma, M.Karolinska Institutet (author)
  • Pin, ElisaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1pmjyje (author)
  • Smith, C. I. E.Karolinska Institutet (author)
  • Stromberg, O. (author)
  • Sällberg Chen, M. (author)
  • Zain, R.Karolinska Institutet (author)
  • Hansson, L. (author)
  • Österborg, A.Karolinska Institutet (author)
  • Karolinska InstitutetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Related titles

  • In:Leukemia: Springer Nature36:2, s. 476-4810887-69241476-5551

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  • Leukemia (Search for host publication in LIBRIS)

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