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Absolute Quantifica...
Absolute Quantification of Pan-Cancer Plasma Proteomes Reveals Unique Signature in Multiple Myeloma
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- Kotol, David (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, S-11428 Stockholm, Sweden.;KTH Royal Inst Technol, Sch Chem, Dept Prot Sci, Div Syst Biol, S-11428 Stockholm, Sweden.
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- Woessmann, Jakob (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Sci Life Lab, S-11428 Stockholm, Sweden.;KTH Royal Inst Technol, Sch Chem, Dept Prot Sci, Div Syst Biol, S-11428 Stockholm, Sweden.
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- Hober, Andreas, 1992- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Sci Life Lab, S-11428 Stockholm, Sweden.;KTH Royal Inst Technol, Sch Chem, Dept Prot Sci, Div Syst Biol, S-11428 Stockholm, Sweden.
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- Alvez, Maria Bueno (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Sci Life Lab, S-11428 Stockholm, Sweden.;KTH Royal Inst Technol, Sch Chem, Dept Prot Sci, Div Syst Biol, S-11428 Stockholm, Sweden.
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- Tran Minh, Khue Hua (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, S-11428 Stockholm, Sweden.;KTH Royal Inst Technol, Sch Chem, Dept Prot Sci, Div Syst Biol, S-11428 Stockholm, Sweden.
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- Pontén, Fredrik (författare)
- Uppsala universitet,Cancerprecisionsmedicin
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- Fagerberg, Linn (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Sci Life Lab, S-11428 Stockholm, Sweden.;KTH Royal Inst Technol, Sch Chem, Dept Prot Sci, Div Syst Biol, S-11428 Stockholm, Sweden.
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- Uhlén, Mathias (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Sci Life Lab, S-11428 Stockholm, Sweden.;KTH Royal Inst Technol, Sch Chem, Dept Prot Sci, Div Syst Biol, S-11428 Stockholm, Sweden.
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- Edfors, Fredrik (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Sci Life Lab, S-11428 Stockholm, Sweden.;KTH Royal Inst Technol, Sch Chem, Dept Prot Sci, Div Syst Biol, S-11428 Stockholm, Sweden.
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(creator_code:org_t)
- MDPI AG, 2023
- 2023
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 15:19
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Mass spectrometry based on data-independent acquisition (DIA) has developed into a powerful quantitative tool with a variety of implications, including precision medicine. Combined with stable isotope recombinant protein standards, this strategy provides confident protein identification and precise quantification on an absolute scale. Here, we describe a comprehensive targeted proteomics approach to profile a pan-cancer cohort consisting of 1800 blood plasma samples representing 15 different cancer types. We successfully performed an absolute quantification of 253 proteins in multiplex. The assay had low intra-assay variability with a coefficient of variation below 20% (CV = 17.2%) for a total of 1013 peptides quantified across almost two thousand injections. This study identified a potential biomarker panel of seven protein targets for the diagnosis of multiple myeloma patients using differential expression analysis and machine learning. The combination of markers, including the complement C1 complex, JCHAIN, and CD5L, resulted in a prediction model with an AUC of 0.96 for the identification of multiple myeloma patients across various cancer patients. All these proteins are known to interact with immunoglobulins.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- DIA
- multiple myeloma
- precision medicine
- targeted proteomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Kotol, David
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Woessmann, Jakob
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Hober, Andreas, ...
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Alvez, Maria Bue ...
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Tran Minh, Khue ...
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Pontén, Fredrik
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Fagerberg, Linn
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Uhlén, Mathias
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Edfors, Fredrik
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Cancers
- Av lärosätet
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Kungliga Tekniska Högskolan
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Uppsala universitet