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Lectin-Functionaliz...
Lectin-Functionalized Polyethylene Glycol for Relief of Mucosal Dryness
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- Blakeley, Matthew (author)
- KTH,Glykovetenskap
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- Sharma, P. K. (author)
- Department of Biomedical Engineering, University of Groningen and University Medical Centre Groningen, Groningen, 9713 AV, Netherlands
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- Kaper, H. J. (author)
- Department of Biomedical Engineering, University of Groningen and University Medical Centre Groningen, Groningen, 9713 AV, Netherlands
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- Bostanci, N. (author)
- Karolinska Institutet
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- Crouzier, Thomas (author)
- KTH,Glykovetenskap,AIMES – Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institutet ; Department of Neuroscience, Karolinska Institutet, Stockholm, 171 77, Sweden
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(creator_code:org_t)
- 2021-11-09
- 2022
- English.
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In: Advanced Healthcare Materials. - : Wiley. - 2192-2640 .- 2192-2659. ; 11:2
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- The importance of lubrication between oral surfaces provided by the salivary film is most acutely apparent when it is disrupted, a prevalent consequence of salivary gland hypofunction experienced with aging, a symptom of certain diseases, or a side effect of some medical interventions. Sufferers report difficulty with speech and oral food processing and collectively is detrimental to quality of life. Polyethylene glycol (PEG) is widely employed as a successful biocompatible boundary lubricant in engineering and biomedical applications. It is hypothesized that the immobilization of PEG to biological materials such as oral epithelial cells and tissue can mimic the salivary film and provide durable relief from the symptoms of mucosal dryness. To do so, PEG is functionalized with a sugar binding lectin (wheat germ agglutinin) to enhance epithelial adhesion through lectin-sugar interactions. Retention and lubricity are characterized on an ex vivo oral tissue tribology rig. WGA-PEG coats and retains on mucin films, oral epithelial cells, and porcine tongue tissue, and offers sustained reduction in coefficient of friction (COF). WGA-PEG could be developed into a useful topical treatment for reducing oral friction and the perception of dry mouth.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Biocompatibility
- Cells
- Food processing
- Friction
- Medical applications
- Polyethylenes
- Proteins
- Tissue
- Tribology
- Boundary lubricants
- Dry mouth
- Epithelial cells
- Functionalised-polyethylene glycol
- Lubrication
- Medical intervention
- Mucosal dryness
- Quality of life
- Salivary glands
- Side effect
- Polyethylene glycols
- macrogol
- mucin
- wheat germ agglutinin
- lectin
- aging
- animal tissue
- Article
- cell adhesion
- controlled study
- epithelium cell
- ex vivo study
- human
- human cell
- lubrication
- mouth epithelium
- mouth mucosa
- nonhuman
- pig
- protein carbohydrate interaction
- saliva
- salivary gland disease
- speech disorder
- animal
- metabolism
- xerostomia
- Animals
- Lectins
- Swine
Publication and Content Type
- ref (subject category)
- art (subject category)
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