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  • Chen, YueHarbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China. (author)

A novel nanoparticle system targeting damaged mitochondria for the treatment of Parkinson's disease

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-315236
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-315236URI
  • https://doi.org/10.1016/j.bioadv.2022.212876DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149866898URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20220706
  • Mitochondrial damage is one of the primary causes of neuronal cell death in Parkinson's disease (PD). In PD patients, the mitochondrial damage can be repaired or irreversible. Therefore, mitochondrial damage repair becomes a promising strategy for PD treatment. In this research, hyaluronic acid nanoparticles (HA-NPs) of different molecular weights are used to protect the mitochondria and salvage the mild and limited damage in mitochondria. The HA-NPs with 2190 k Dalton (kDa) HA can improve the mitochondrial function of SH-SY5Y cells and PTEN induced putative kinase 1 (PINK1) knockout mouse embryo fibroblast (MEF) cells. In cases of irreversible damage, NPs with ubiquitin specific peptidase 30 (USP30) siRNA are used to promote mitophagy. Meanwhile, by adding PINK1 antibodies, the NPs can selectively target the irreversibly damaged mitochondria, preventing the excessive clearance of healthy mitochondria.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zhang, BosongHarbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China. (author)
  • Yu, LinaHarbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China. (author)
  • Zhang, JinyuHarbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China. (author)
  • Zhao, YufangHarbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China. (author)
  • Yao, LifenHarbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin 150080, Peoples R China. (author)
  • Yan, HongjiKarolinska Institutet,KTH,Glykovetenskap,AIMES Ctr Adv Integrated Med & Engn Sci, Karolinska Inst, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden.(Swepub:kth)u1qjm063 (author)
  • Tian, WeimingHarbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China. (author)
  • Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China.Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin 150080, Peoples R China. (creator_code:org_t)

Related titles

  • In:Biomaterials Advances: Elsevier BV1382772-95162772-9508

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Chen, Yue
Zhang, Bosong
Yu, Lina
Zhang, Jinyu
Zhao, Yufang
Yao, Lifen
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Yan, Hongji
Tian, Weiming
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Karolinska Institutet

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