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Molecular nanoinfor...
Molecular nanoinformatics approach assessing the biocompatibility of biogenic silver nanoparticles with channelized intrinsic steatosis and apoptosis
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- Panda, Pritam Kumar, PhD Student, 1991- (författare)
- Uppsala universitet,Materialteori,Condensed Matter Theory Group
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- Kumari, P. (författare)
- Masaryk Univ, Fac Sci, RECETOX, Kotlarska 2, Brno 61137, Czech Republic.;Vinoba Bhave Univ, Adv Sci & Technol Res Ctr, Hazaribagh 825001, India.
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- Patel, P. (författare)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India.
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- Samal, S. K. (författare)
- Karolinska Institutet
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- Mishra, S. (författare)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India.
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- Tambuwala, M. M. (författare)
- Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland.
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- Dutt, A. (författare)
- UNAM, Inst Invest Mat, Cdmx 04510, Mexico.
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- Hilscherová, K. (författare)
- Masaryk Univ, Fac Sci, RECETOX, Kotlarska 2, Brno 61137, Czech Republic.
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- Mishra, Y. K. (författare)
- Univ Southern Denmark, Mads Clausen Inst, NanoSYD, Alsion 2, DK-6400 Sonderborg, Denmark.
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- Varma, R. S. (författare)
- Palacky Univ Olomouc, Czech Adv Technol & Res Inst, Reg Ctr Adv Technol & Mat, Slechtitelu 27, Olomouc 78371, Czech Republic.
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- Suar, M. (författare)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India.
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- Ahuja, Rajeev, 1965- (författare)
- Uppsala universitet,KTH,Egenskaper,Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, Uppsala, SE-751 20, Sweden,Materialteori,Royal Inst Technol KTH, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden.
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- Verma, Suresh K. (författare)
- Uppsala universitet,Materialteori,KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India.,Condensed Matter Theory Group
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(creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: Green Chemistry. - : Royal Society of Chemistry (RSC). - 1463-9262 .- 1463-9270. ; 24:3, s. 1190-1210
- Relaterad länk:
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https://doi.org/10.1...
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https://pubs.rsc.org...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The developmental rapidity of nanotechnology poses higher risks of exposure to humans and the environment through manufactured nanomaterials. The multitude of biological interfaces, such as DNA, proteins, membranes, and cell organelles, which come in contact with nanoparticles, is influenced by colloidal and dynamic forces. Consequently, the ensued nano-bio interface depends on dynamic forces, encompasses many cellular absorption mechanisms along with various biocatalytic activities, and biocompatibility that needs to be investigated in detail. Addressing the issue, the study offers a novel green synthesis strategy for antibacterial AgNPs with higher biocompatibility and elucidates the mechanistic in vivo biocompatibility of silver nanoparticles (AgNPs) at the cellular and molecular levels. The analysis ascertained the biosynthesis of G-AgNPs with the size of 25 ± 10 nm and zeta potential of-29.2 ± 3.0 mV exhibiting LC50 of 47.2 μg mL-1 in embryonic zebrafish. It revealed the mechanism as a consequence of abnormal physiological metabolism in oxidative stress and neutral lipid metabolism due to dose-dependent interaction with proteins such as he1a, sod1, PEX protein family, and tp53 involving amino acids such as arginine, glutamine and leucine leading to improper apoptosis. The research gave a detailed insight into the role of diverse AgNPs-protein interactions with a unique combinatorial approach from first-principles density functional theory and in silico analyses, thus paving a new pathway to comprehending their intrinsic properties and usage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Amino acids
- Biochemistry
- Cell death
- Cell proliferation
- Density functional theory
- Dynamics
- Metabolism
- Metal nanoparticles
- Physiology
- Proteins
- Synthesis (chemical)
- Biogenics
- Biological interface
- Cell organelle
- Colloidal forces
- DNA-proteins
- Dynamic forces
- Manufactured nanomaterials
- Nanoinformatics
- Protein membrane
- Risk of exposures
- Biocompatibility
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Panda, Pritam Ku ...
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Kumari, P.
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Patel, P.
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Samal, S. K.
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Mishra, S.
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Tambuwala, M. M.
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visa fler...
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Dutt, A.
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Hilscherová, K.
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Mishra, Y. K.
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Varma, R. S.
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Suar, M.
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Ahuja, Rajeev, 1 ...
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Verma, Suresh K.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Medicinsk biotek ...
- Artiklar i publikationen
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Green Chemistry
- Av lärosätet
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Kungliga Tekniska Högskolan
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Uppsala universitet
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Karolinska Institutet