WFRF:(Waddington James C.)
Sökning: WFRF:(Waddington James C.) > (2020-2022) > Omics and Multi-Omi...
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Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis
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- Gurke, Robert (författare)
- Fraunhofer Inst Translat Med & Pharmacol ITMP, Theodor Stern Kai 7, D-60596 Frankfurt, Germany.;Fraunhofer Cluster Excellence Immune Mediated Dis, Theodor Stern Kai 7, D-60596 Frankfurt, Germany.;Fraunhofer Cluster Excellence Immune Mediated Dis, Inst Clin Pharmacol, Pharmazentrum Frankfurt ZAFES, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
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- Bendes, Annika (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Bowes, John (författare)
- Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Ctr, Manchester M13 9WU, Lancs, England.;Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Ctr Musculoskeletal Res,Ctr Genet & Genom Versus, Manchester M13 9PT, Lancs, England.
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- Fraunhofer Inst Translat Med & Pharmacol ITMP, Theodor Stern Kai 7, D-60596 Frankfurt, Germany;Fraunhofer Cluster Excellence Immune Mediated Dis, Theodor Stern Kai 7, D-60596 Frankfurt, Germany.;Fraunhofer Cluster Excellence Immune Mediated Dis, Inst Clin Pharmacol, Pharmazentrum Frankfurt ZAFES, Theodor Stern Kai 7, D-60590 Frankfurt, Germany. Affinitets-proteomik (creator_code:org_t)
- 2022-09-24
- 2022
- Engelska.
- Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 10:10
- Forskningsöversikt (refereegranskat)
Abstract
Ämnesord
Stäng
- The definitive diagnosis and early treatment of many immune-mediated inflammatory diseases (IMIDs) is hindered by variable and overlapping clinical manifestations. Psoriatic arthritis (PsA), which develops in similar to 30% of people with psoriasis, is a key example. This mixed-pattern IMID is apparent in entheseal and synovial musculoskeletal structures, but a definitive diagnosis often can only be made by clinical experts or when an extensive progressive disease state is apparent. As with other IMIDs, the detection of multimodal molecular biomarkers offers some hope for the early diagnosis of PsA and the initiation of effective management and treatment strategies. However, specific biomarkers are not yet available for PsA. The assessment of new markers by genomic and epigenomic profiling, or the analysis of blood and synovial fluid/tissue samples using proteomics, metabolomics and lipidomics, provides hope that complex molecular biomarker profiles could be developed to diagnose PsA. Importantly, the integration of these markers with high-throughput histology, imaging and standardized clinical assessment data provides an important opportunity to develop molecular profiles that could improve the diagnosis of PsA, predict its occurrence in cohorts of individuals with psoriasis, differentiate PsA from other IMIDs, and improve therapeutic responses. In this review, we consider the technologies that are currently deployed in the EU IMI2 project HIPPOCRATES to define biomarker profiles specific for PsA and discuss the advantages of combining multi-omics data to improve the outcome of PsA patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- psoriatic diseases
- psoriatic arthritis
- psoriasis
- multi-omics
- data integration
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