Robust automated radiation therapy treatment planning using scenario-specific dose prediction and robust dose mimicking

• Purpose: We present a framework for robust automated treatment planning using machine learning, comprising scenario-specific dose prediction and robust dose mimicking. Methods: The scenario dose prediction pipeline is divided into the prediction of nominal dose from input image and the prediction of scenario dose from nominal dose, each using a deep learning model with U-net architecture. By using a specially developed dose–volume histogram–based loss function, the predicted scenario doses are ensured sufficient target coverage despite the possibility of the training data being non-robust. Deliverable plans may then be created by solving a robust dose mimicking problem with the predictions as scenario-specific reference doses. Results: Numerical experiments are performed using a data set of 52 intensity-modulated proton therapy plans for prostate patients. We show that the predicted scenario doses resemble their respective ground truth well, in particular while having target coverage comparable to that of the nominal scenario. The deliverable plans produced by the subsequent robust dose mimicking were showed to be robust against the same scenario set considered for prediction. Conclusions: We demonstrate the feasibility and merits of the proposed methodology for incorporating robustness into automated treatment planning algorithms. 

Ämnesord

NATURVETENSKAP  -- Data- och informationsvetenskap -- Datavetenskap (hsv//swe)

NATURAL SCIENCES  -- Computer and Information Sciences -- Computer Sciences (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)

Nyckelord

dose mimicking

knowledge-based planning

robust optimization

scenario dose prediction

Automation

Deep learning

Knowledge based systems

Optimization

Radiotherapy

Dose mimicing

Input image

Knowledge based planning

Learning models

NET architecture

Radiation therapy treatment planning

Target coverage

Treatment planning

Forecasting

adult

algorithm

article

controlled study

dose volume histogram

feasibility study

human

loss of function mutation

male

pipeline

prediction

prostate

proton therapy

intensity modulated radiation therapy

organs at risk

procedures

radiotherapy dosage

radiotherapy planning system

Humans

Radiotherapy Planning

Computer-Assisted

Radiotherapy

Intensity-Modulated

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)