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SOdium-glucose CO-t...
SOdium-glucose CO-transporter inhibition in patients with newly detected Glucose Abnormalities and a recent Myocardial Infarction (SOCOGAMI)
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- Lundin, Magnus (författare)
- Karolinska Institutet
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- Ferrannini, Giulia (författare)
- Karolinska Institutet
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- Mellbin, Linda (författare)
- Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
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- Johansson, Isabelle (författare)
- Karolinska Institutet
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- Norhammar, Anna (författare)
- Karolinska Institutet
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- Näsman, Per, Docent, 1954- (författare)
- KTH,Centrum för transportstudier, CTS
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- Shahim, Bahira (författare)
- Karolinska Institutet
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- Smetana, Stina (författare)
- Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
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- Venkateshvaran, Ashwin (författare)
- Karolinska Institutet
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- Wang, Anne (författare)
- Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
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- Sorensson, Peder (författare)
- Karolinska Institutet
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- Ryden, Lars (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Med Solna, Stockholm, Sweden;Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden. (creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Diabetes Research and Clinical Practice. - : Elsevier BV. - 0168-8227 .- 1872-8227. ; 193, s. 110141-
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims/hypothesis: Established dysglycaemia (impaired glucose tolerance [IGT] or type 2 diabetes [T2DM]) is a risk factor for further cardiovascular events in patients with coronary artery disease. Sodium-glucose cotransporter 2 inhibitors reduce this risk. The aim of the present investigation was to test the hypothesis that empagliflozin exerts beneficial effects on myocardial function in patients with a recent acute coronary syndrome and newly detected dysglycaemia. Methods: Forty-two patients (mean age 67.5 years, 81 % male) with recent myocardial infarction (n = 36) or unstable angina (n = 6) and newly detected IGT (n = 27) or T2DM (n = 15) were randomised to 25 mg of empagliflozin daily (n = 20) or placebo (n = 22) on top of ongoing therapy. They were investigated with oral glucose tolerance tests, stress-perfusion cardiac magnetic resonance imaging (CMR) and echocardiography at three occasions: before randomisation, after seven months on study drug and three months following cessation of such drug. Primary outcome was a change in left ventricular (LV) end-diastolic volume (LVEDV) and secondary outcomes were a change in a) systolic and diastolic LV function; b) coronary flow reserve; c) myocardial extracellular volume (ECV) in non-infarcted myocardium; d) aortic pulse wave velocity. Results: Empagliflozin induced a significant decrease in fasting and post load glucose (p < 0.05) and body weight (p < 0.01). Empagliflozin did not influence LVEDV, LV systolic or mass indexes, coronary flow reserve, ECV or aortic pulse wave velocity. Echocardiographic indices of LV diastolic function (E/e' and mitral E/A ratio) were not influenced. No safety concerns were identified. Conclusions/interpretation: Empagliflozin had predicted effects on the dysglycaemia but did not influence vari-ables expressing LV function, coronary flow reserve and ECV. An explanation may be that the LV function of the patients was within the normal range.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Dysglycaemia
- Acute coronary syndrome
- SGLT-2-inhibition
- Empagliflozin
- Cardiac magnetic resonance tomography
- Echocardiography
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lundin, Magnus
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Ferrannini, Giul ...
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Mellbin, Linda
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Johansson, Isabe ...
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Norhammar, Anna
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Näsman, Per, Doc ...
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visa fler...
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Shahim, Bahira
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Smetana, Stina
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Venkateshvaran, ...
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Wang, Anne
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Sorensson, Peder
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Ryden, Lars
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Karolinska Institutet