Cell transcriptomic atlas of the non-human primate Macaca fascicularis

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QC 20230116
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
Wnt protein
transcriptome
cell
genetic analysis
phylogenetics
primate
adult
animal cell
animal experiment
animal tissue
Article
cell interaction
cell isolation
cell transcriptomic atlas
cellular
subcellular and molecular biological phenomena and functions
controlled study
female
genetic disorder
Macaca fascicularis
male
mouse
nonhuman
phylogeny
RNA sequencing
single cell RNA seq
single nucleus RNA sequencing
species comparison
virus infection
Wnt signaling
animal
genetics
virus
Animals
Primates
Viruses

Wei, X. (author)
Liu, C. (author)
Volpe, G. (author)
Zhuang, Z. (author)
Zou, X. (author)
Wang, Z. (author)
Pan, T. (author)
Yuan, Y. (author)
Zhang, X. (author)
Fan, P. (author)
Guo, P. (author)
Lai, Y. (author)
Lei, Y. (author)
Liu, X. (author)
Yu, F. (author)
Shangguan, S. (author)
Lai, G. (author)
Deng, Q. (author)
Liu, Y. (author)
Wu, L. (author)
Shi, Q. (author)
Yu, H. (author)
Huang, Y. (author)
Cheng, M. (author)
Xu, J. (author)
Wang, M. (author)
Wang, C. (author)
Zhang, Y. (author)
Xie, D. (author)
Yang, Y. (author)
Yu, Y. (author)
Zheng, H. (author)
Wei, Y. (author)
Huang, F. (author)
Lei, J. (author)
Huang, W. (author)
Zhu, Z. (author)
Lu, H. (author)
Wang, B. (author)
Chen, F. (author)
Yang, T. (author)
Du, W. (author)
Chen, J. (author)
Xu, S. (author)
An, J. (author)
Ward, C. (author)
Pei, Z. (author)
Wong, C. -W (author)
Zhang, H. (author)
Liu, M. (author)
Qin, B. (author)
Schambach, A. (author)
Isern, J. (author)
Feng, L. (author)
Guo, X. (author)
Liu, Z. (author)
Sun, Q. (author)
Maxwell, P. H. (author)
Barker, N. (author)
Muñoz-Cánoves, P. (author)
Gu, Y. (author)
Mulder, JanKarolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u14o2jvk (author)
Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi(Swepub:kth)u1dulvmw (author)
Tan, T. (author)
Liu, S. (author)
Yang, H. (author)
Wang, J. (author)
Hou, Y. (author)
Xu, X. (author)
Esteban, M. A. (author)
Liu, L. (author)
KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)

By the author/editor: Han, L.; Wei, X.; Liu, C.; Volpe, G.; Zhuang, Z.; Zou, X.; show more...; Wang, Z.; Pan, T.; Yuan, Y.; Zhang, X.; Fan, P.; Guo, P.; Lai, Y.; Lei, Y.; Liu, X.; Yu, F.; Shangguan, S.; Lai, G.; Deng, Q.; Liu, Y.; Wu, L.; Shi, Q.; Yu, H.; Huang, Y.; Cheng, M.; Xu, J.; Wang, M.; Wang, C.; Zhang, Y.; Xie, D.; Yang, Y.; Yu, Y.; Zheng, H.; Wei, Y.; Huang, F.; Lei, J.; Huang, W.; Zhu, Z.; Lu, H.; Wang, B.; Chen, F.; Yang, T.; Du, W.; Chen, J.; Xu, S.; An, J.; Ward, C.; Pei, Z.; Wong, C. -W; Zhang, H.; Liu, M.; Qin, B.; Schambach, A.; Isern, J.; Feng, L.; Guo, X.; Liu, Z.; Sun, Q.; Maxwell, P. H.; Barker, N.; Muñoz-Cánoves, P ...; Gu, Y.; Mulder, Jan; Uhlén, Mathias; Tan, T.; Liu, S.; Yang, H.; Wang, J.; Hou, Y.; Xu, X.; Esteban, M. A.; Liu, L.; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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