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Wireless optoelectr...
Wireless optoelectronic devices for vagus nerve stimulation in mice
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- Donahue, Mary (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Silverå Ejneby, Malin (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Wallenberg Centre for Molecular Medicine
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- Jakesova, Marie (författare)
- Brno Univ Technol, Cent European Inst Technol, Bioelect Mat & Devices Lab, Purkynova 123, Brno 61200, Czech Republic.
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- Caravaca, April S. (författare)
- Karolinska Inst, Ctr Mol Med, Dept Med, Ctr Bioelect Med,Lab Immunobiol, Stockholm, Sweden.;Karolinska Univ Hosp, MedTechLabs, Stockholm Ctr Bioelect Med, Solna, Sweden.
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- Andersson, Gabriel (författare)
- KTH,Matematik (Inst.),KTH, Sweden
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- Sahalianov, Ihor (författare)
- Brno Univ Technol, Cent European Inst Technol, Bioelect Mat & Devices Lab, Purkynova 123, Brno 61200, Czech Republic.
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- Derek, Vedran (författare)
- Univ Zagreb, Fac Sci, Dept Phys, Bijenicka C 32, Zagreb 10000, Croatia.
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- Hult, Henrik, 1975- (författare)
- KTH,Matematik (Inst.),Karolinska Univ Hosp, MedTechLabs, Stockholm Ctr Bioelect Med, Solna, Sweden.
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- Olofsson, Peder S. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Feinstein Inst Med Res, NY USA
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- Glowacki, Eric (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Brno Univ Technol, Czech Republic
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(creator_code:org_t)
- 2022-12-09
- 2022
- Engelska.
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Ingår i: Journal of Neural Engineering. - : IOP Publishing. - 1741-2560 .- 1741-2552. ; 19:6, s. 066031-
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Abstract
Ämnesord
Stäng
- Objective. Vagus nerve stimulation (VNS) is a promising approach for the treatment of a wide variety of debilitating conditions, including autoimmune diseases and intractable epilepsy. Much remains to be learned about the molecular mechanisms involved in vagus nerve regulation of organ function. Despite an abundance of well-characterized rodent models of common chronic diseases, currently available technologies are rarely suitable for the required long-term experiments in freely moving animals, particularly experimental mice. Due to challenging anatomical limitations, many relevant experiments require miniaturized, less invasive, and wireless devices for precise stimulation of the vagus nerve and other peripheral nerves of interest. Our objective is to outline possible solutions to this problem by using nongenetic light-based stimulation. Approach. We describe how to design and benchmark new microstimulation devices that are based on transcutaneous photovoltaic stimulation. The approach is to use wired multielectrode cuffs to test different stimulation patterns, and then build photovoltaic stimulators to generate the most optimal patterns. We validate stimulation through heart rate analysis. Main results. A range of different stimulation geometries are explored with large differences in performance. Two types of photovoltaic devices are fabricated to deliver stimulation: photocapacitors and photovoltaic flags. The former is simple and more compact, but has limited efficiency. The photovoltaic flag approach is more elaborate, but highly efficient. Both can be used for wireless actuation of the vagus nerve using light impulses. Significance. These approaches can enable studies in small animals that were previously challenging, such as long-term in vivo studies for mapping functional vagus nerve innervation. This new knowledge may have potential to support clinical translation of VNS for treatment of select inflammatory and neurologic diseases.
Ämnesord
- NATURVETENSKAP -- Biologi -- Annan biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Other Biological Topics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Annan elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Other Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Nyckelord
- neuromodulation
- wireless stimulator
- peripheral nerve stimulation
- optoelectronics
- flexible electronics
- vagus nerve stimulation
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- Av författaren/redakt...
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Donahue, Mary
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Silverå Ejneby, ...
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Jakesova, Marie
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Caravaca, April ...
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Andersson, Gabri ...
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Sahalianov, Ihor
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visa fler...
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Derek, Vedran
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Hult, Henrik, 19 ...
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Olofsson, Peder ...
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Glowacki, Eric
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Annan biologi
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Elektroteknik oc ...
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och Annan elektrotek ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Biomedicinsk lab ...
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Journal of Neura ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet
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Linköpings universitet