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A brain atlas of sy...
A brain atlas of synapse protein lifetime across the mouse lifespan
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- Bulovaite, Edita (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.
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- Qiu, Zhen (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.
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- Kratschke, Maximilian (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.
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- Zgraj, Adrianna (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.
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- Fricker, David G. (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.
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- Tuck, Eleanor J. (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.
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- Gokhale, Ragini (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.
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- Koniaris, Babis (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.;Edinburgh Napier Univ, Sch Comp, Edinburgh EH10 5DT, Scotland.
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- Jami, Shekib A. (författare)
- Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Brain Res Inst, Integrat Ctr Learning & Memory, Los Angeles, CA 90095 USA.
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- Merino-Serrais, Paula (författare)
- UPM, Lab Cajal Circuitos Cort, Ctr Tecnol Biomed, Madrid 28223, Spain.;CSIC, Inst Cajal, Madrid 28002, Spain.
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- Husi, Elodie (författare)
- Univ Geneva, Fac Med, Dept Basic Neurosci, CH-1211 Geneva, Switzerland.
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- Mendive-Tapia, Lorena (författare)
- Univ Edinburgh, Ctr Inflammat Res, Edinburgh EH16 4TJ, Scotland.
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- Vendrell, Marc (författare)
- Univ Edinburgh, Ctr Inflammat Res, Edinburgh EH16 4TJ, Scotland.
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O'Dell, Thomas J. (författare)
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DeFelipe, Javier (författare)
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- Komiyama, Noboru H. (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.;Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain SIDB, Edinburgh EH8 9XD, Scotland.;Univ Edinburgh, Patrick Wild Ctr Res Autism, Ctr Discovery Brain Sci, Fragile Syndrome & Intellectual Disabil 10, Edinburgh EH8 9XD, Scotland.;Univ Edinburgh, Muir Maxwell Epilepsy Ctr, Edinburgh EH8 9XD, Scotland.
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- Holtmaat, Anthony (författare)
- Univ Geneva, Fac Med, Dept Basic Neurosci, CH-1211 Geneva, Switzerland.
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- Fransén, Erik, 1962- (författare)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST),Science for Life Laboratory, SciLifeLab
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- Grant, Seth G. N. (författare)
- Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.;Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain SIDB, Edinburgh EH8 9XD, Scotland.
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Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland Univ Edinburgh, Ctr Clin Brain Sci, Genes Cognit Program, Edinburgh EH16 4SB, Scotland.;Edinburgh Napier Univ, Sch Comp, Edinburgh EH10 5DT, Scotland. (creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Neuron. - : Elsevier BV. - 0896-6273 .- 1097-4199. ; 110:24, s. 4057-
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The lifetime of proteins in synapses is important for their signaling, maintenance, and remodeling, and for memory duration. We quantified the lifetime of endogenous PSD95, an abundant postsynaptic protein in excitatory synapses, at single-synapse resolution across the mouse brain and lifespan, generating the Protein Lifetime Synaptome Atlas. Excitatory synapses have a wide range of PSD95 lifetimes extending from hours to several months, with distinct spatial distributions in dendrites, neurons, and brain regions. Synapses with short protein lifetimes are enriched in young animals and in brain regions controlling innate behaviors, whereas synapses with long protein lifetimes accumulate during development, are enriched in the cortex and CA1 where memories are stored, and are preferentially preserved in old age. Synapse protein lifetime increases throughout the brain in a mouse model of autism and schizophrenia. Protein lifetime adds a further layer to synapse diversity and enriches prevailing concepts in brain development, aging, and disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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Neuron
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Bulovaite, Edita
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Qiu, Zhen
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Kratschke, Maxim ...
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Zgraj, Adrianna
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Fricker, David G ...
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Tuck, Eleanor J.
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visa fler...
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Gokhale, Ragini
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Koniaris, Babis
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Jami, Shekib A.
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Merino-Serrais, ...
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Husi, Elodie
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Mendive-Tapia, L ...
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Vendrell, Marc
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O'Dell, Thomas J ...
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DeFelipe, Javier
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Komiyama, Noboru ...
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Holtmaat, Anthon ...
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Fransén, Erik, 1 ...
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Grant, Seth G. N ...
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- MEDICIN OCH HÄLSOVETENSKAP
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