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Proteomic Analysis ...
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Martinson, NeilUniv Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, ZA-2000 Johannesburg, South Africa.
(author)
Proteomic Analysis of Mucosal and Systemic Responses to SARS-CoV-2 Antigen
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-02-02
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MDPI AG,2023
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-325087
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-325087URI
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https://doi.org/10.3390/vaccines11020334DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152093446URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20230329
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The mucosal environment of the upper respiratory tract is the first barrier of protection against SARS-CoV-2 transmission. However, the mucosal factors involved in viral transmission and potentially modulating the capacity to prevent such transmission have not fully been identified. In this pilot proteomics study, we compared mucosal and systemic compartments in a South African cohort of vaccinated and unvaccinated individuals undergoing maxillofacial surgery with previous history of COVID-19 or not. Inflammatory profiles were analyzed in plasma, nasopharyngeal swabs, and nasal and oral tissue explant cultures, using Olink and Luminex technologies. SARS-CoV-2-specific antibody levels were measured in serum and tissue explants. An increased pro-inflammatory proteomic profile was measured in the nasal compartment compared to plasma. However, IP-10 and MIG levels were higher in secretions than in nasal tissue, and the opposite was observed for TGF-beta. Nasal anti-SARS-CoV-2 spike IgG correlated with mucosal MIG expression for all participants. A further positive correlation was found with IP-10 in BioNTech/Pfizer-vaccinated individuals. Systemic levels of anti-SARS-CoV-2 spike IgG elicited by this vaccine correlated with plasma IL-10, IL-6 and HBD4. Proteomic profiles measured in mucosal tissues and secretions using combined technologies could reveal correlates of protection at the mucosal portals of viral entry.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Gordhan, BhavnaUniv Witwatersrand, Natl Res Fdn, Fac Hlth Sci, Ctr Excellence Biomed TB Res, Johannesburg, South Africa.;Natl Hlth Lab Serv, ZA-2000 Johannesburg, South Africa.
(author)
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Petkov, StefanKarolinska Inst, Dept Microbiol Tumor & Cell Biol, SE-17165 Solna, Sweden.
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Pillay, Azure-DeeUniv Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, ZA-2000 Johannesburg, South Africa.
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Seiphetlo, ThabisoUniv Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, ZA-2000 Johannesburg, South Africa.
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Singh, NatashaUniv Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, ZA-2000 Johannesburg, South Africa.
(author)
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Otwombe, KennedyUniv Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, ZA-2000 Johannesburg, South Africa.;Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, ZA-2000 Johannesburg, South Africa.
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Lebina, LimakatsoUniv Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, ZA-2000 Johannesburg, South Africa.
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Fredolini, ClaudiaKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u11xul3s
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Chiodi, FrancescaKarolinska Institutet
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Fox, JulieKings Coll London, Guys & St ThomasNHS Fdn Trust, Guys & St, London SE1 9RT, England.
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Kana, BaveshUniv Witwatersrand, Natl Res Fdn, Fac Hlth Sci, Ctr Excellence Biomed TB Res, Johannesburg, South Africa.
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Herrera, CarolinaImperial Coll London, Dept Infect Dis, London W2 1PG, England.
(author)
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Univ Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, ZA-2000 Johannesburg, South Africa.Univ Witwatersrand, Natl Res Fdn, Fac Hlth Sci, Ctr Excellence Biomed TB Res, Johannesburg, South Africa.;Natl Hlth Lab Serv, ZA-2000 Johannesburg, South Africa.
(creator_code:org_t)
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In:Vaccines: MDPI AG11:22076-393X
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Martinson, Neil
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Gordhan, Bhavna
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Petkov, Stefan
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Pillay, Azure-De ...
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Seiphetlo, Thabi ...
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Singh, Natasha
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Otwombe, Kennedy
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Lebina, Limakats ...
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Fredolini, Claud ...
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Fox, Julie
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