Sökning: WFRF:(Song Huan) >
Early osteoimmunomo...
Early osteoimmunomodulation by mucin hydrogels augments the healing and revascularization of rat critical-size calvarial bone defects
-
- Chen, Song (författare)
- Soochow Univ, Affiliated Hosp 1, Suzhou Med Coll, Orthoped Inst,Dept Orthoped Surg, Suzhou, Jiangsu, Peoples R China.
-
- Wang, Huan (författare)
- Soochow Univ, Affiliated Hosp 1, Suzhou Med Coll, Orthoped Inst,Dept Orthoped Surg, Suzhou, Jiangsu, Peoples R China.
-
- Liu, Dachuan (författare)
- Soochow Univ, Affiliated Hosp 1, Suzhou Med Coll, Orthoped Inst,Dept Orthoped Surg, Suzhou, Jiangsu, Peoples R China.
-
visa fler...
-
- Bai, Jianzhong (författare)
- Soochow Univ, Affiliated Hosp 1, Suzhou Med Coll, Orthoped Inst,Dept Orthoped Surg, Suzhou, Jiangsu, Peoples R China.
-
- Haugen, Havard Jostein (författare)
- Univ Oslo, Inst Clin Dent, Dept Biomat, POB 1109 Blindern, N-0376 Oslo, Norway.
-
- Li, Bin (författare)
- Soochow Univ, Affiliated Hosp 1, Suzhou Med Coll, Orthoped Inst,Dept Orthoped Surg, Suzhou, Jiangsu, Peoples R China.
-
- Yan, Hongji (författare)
- KTH,Glykovetenskap,Albanova VinnExcellence Center for Protein Technology, ProNova,Center for the Advancement of Integrated Medical and Engineering Sciences, AIMES,Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
-
visa färre...
-
Soochow Univ, Affiliated Hosp 1, Suzhou Med Coll, Orthoped Inst,Dept Orthoped Surg, Suzhou, Jiangsu, Peoples R China Univ Oslo, Inst Clin Dent, Dept Biomat, POB 1109 Blindern, N-0376 Oslo, Norway. (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
-
Ingår i: BIOACTIVE MATERIALS. - : Elsevier BV. - 2452-199X. ; 25, s. 176-188
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The design principle of osteogenic bone grafts has shifted from immunological inertness to limiting foreign body response to combined osteoimmunomodulatory activity to promote high-quality endogenous bone regeneration. Recently developed immunomodulatory mucin hydrogels have been shown to elicit very low complement activation and suppress macrophage release and activation after implantation in vivo. However, their immunoregulatory activity has not yet been studied in the context of tissue repair. Herein, we synthesized mucinmonetite composite materials and investigated their early osteoimmunomodulation using a critical-size rat bone defect model. We demonstrated that the composites can polarize macrophages towards the M2 phenotype at weeks 1 and 2. The early osteoimmunomodulation enhanced early osteogenesis and angiogenesis and ultimately promoted fracture healing and engraftment (revascularization of the host vasculature) at weeks 6 and 12. Overall, we demonstrated the applicability of mucin-based immunomodulatory biomaterials to enhance tissue repair in tissue engineering and regenerative medicine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- Mucin hydrogels
- Monetite
- osteoimmunomodulation
- Bone
- Revascularization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas