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ERβ and Inflammation
ERβ and Inflammation
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- Hases, Linnea (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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- Archer, Amena (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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- Williams, Cecilia, Professor, 1969- (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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(creator_code:org_t)
- 2022-09-16
- 2022
- Engelska.
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Ingår i: Advances in Experimental Medicine and Biology. - Cham : Springer Nature. ; 1390, s. 213-225
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Estrogen, through the regulation of cytokine production, can act both as pro-inflammatory and anti-inflammatory signals dependent on the tissue context. In breast cancer cells, ERα is known to modulate inflammatory signaling through interaction with NFκB. Whether ERβ has a role in inflammation is less explored. Low levels of ERβ have been corroborated in several immune-related organs and, for example, in colonic epithelial cells. Specifically, an impact of ERβ on colitis and colitis-associated colorectal cancer (CRC) is experimentally supported, using ERβ-selective agonists, full-body ERβ knockout mice and, most recently, intestinal epithelial-specific knockout mice. An intricate crosstalk between ERβ and TNFα/NFκB signaling in the colon is supported, and ERβ activation appears to reduce macrophage infiltration also during high fat diet (HFD)-induced colon inflammation. Finally, the gut microbiota plays a fundamental role in the pathogenesis of colitis and ERβ has been indicated to modulate the microbiota diversity during colitis and colitis-induced CRC. ERβ is thus proposed to protect against colitis, by modulating NFκB signaling, immune cell infiltration, and/or microbiota composition. Selective activation of ERβ may therefore constitute a suitable preventative approach for the treatment of for example colitis-associated CRC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Circadian clock
- Colon
- Colorectal cancer
- Estrogen receptor
- Gut microbiota
- NFκB
- Animals
- Colitis
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Estrogens
- Inflammation
- Mice
- Mice
- Knockout
- Tumor Necrosis Factor-alpha
- tumor necrosis factor
- estrogen
- cell infiltration
- colitis-associated cancer
- epithelium cell
- immunocompetent cell
- intestine flora
- lipid diet
- macrophage
- NF kB signaling
- nonhuman
- pathogenesis
- animal
- genetics
- knockout mouse
- mouse
- pathology
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