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A Longitudinal Stud...
A Longitudinal Study of Individual Radiation Responses in Pediatric Patients Treated with Proton and Photon Radiotherapy, and Interventional Cardiology : Rationale and Research Protocol of the HARMONIC Project
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- Andreassi, Maria Grazia (författare)
- CNR Natl Res Council Inst Clin Physiol, I-56125 Pisa, Italy.
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- Haddy, Nadia (författare)
- Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth, Radiat Epidemiol Team, INSERM U1018,Gustave Roussy, F-94805 Villejuif, France.
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- Harms-Ringdahl, Mats, 1944- (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
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- Campolo, Jonica (författare)
- ASST Grande Osped Metropolitano Niguarda, CNR Natl Res Council Inst Clin Physiol, I-20162 Milan, Italy.
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- Borghini, Andrea (författare)
- CNR Natl Res Council Inst Clin Physiol, I-56125 Pisa, Italy.
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- Chevalier, Francois (författare)
- Univ Caen Normandy, UMR6252 CIMAP, CEA, CNRS,ENSICAEN, F-14000 Caen, France.;Adv Resource Ctr HADrontherapy Europe ARCHADE, F-14000 Caen, France.
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- Schwenk, Jochen M. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Fresneau, Brice (författare)
- Univ Paris Saclay, Dept Children & Adolescents Oncol, Gustave Roussy, F-94805 Villejuif, France.;Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth, Canc & Radiat Team, INSERM U1018,Gustave Roussy, F-94805 Villejuif, France.
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- Bolle, Stephanie (författare)
- Univ Paris Saclay, Dept Radiat Therapy, Gustave Roussy, F-94805 Villejuif, France.
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- Fuentes, Manuel (författare)
- Univ Salamanca, Dept Med, CSIC USAL, Canc Res Ctr IBMCC,IBSAL,CSIC, Campus Miguel de Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, Canc Res Ctr IBMCC, Gen Serv Cytometry, Prote Unit,CSIC USAL,IBSAL,CSIC, Campus Miguel de Unamuno S-N, Salamanca 37007, Spain.
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- Haghdoost, Siamak, 1968- (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,CEA-CNRS-ENSICAEN-University of Caen Normandy, France; Advanced Resource Center for HADrontherapy in Europe (ARCHADE), France,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.;Univ Caen Normandy, UMR6252 CIMAP, CEA, CNRS,ENSICAEN, F-14000 Caen, France.;Adv Resource Ctr HADrontherapy Europe ARCHADE, F-14000 Caen, France.
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CNR Natl Res Council Inst Clin Physiol, I-56125 Pisa, Italy Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth, Radiat Epidemiol Team, INSERM U1018,Gustave Roussy, F-94805 Villejuif, France. (creator_code:org_t)
- MDPI AG, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 24:9, s. 8416-
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission that aimed to improve the understanding of the long-term ionizing radiation (IR) risks for pediatric patients. In this paper, we provide a detailed overview of the rationale, design, and methods for the biological aspect of the project with objectives to provide a mechanistic understanding of the molecular pathways involved in the IR response and to identify potential predictive biomarkers of individual response involved in long-term health risks. Biological samples will be collected at three time points: before the first exposure, at the end of the exposure, and one year after the exposure. The average whole-body dose, the dose to the target organ, and the dose to some important out-of-field organs will be estimated. State-of-the-art analytical methods will be used to assess the levels of a set of known biomarkers and also explore high-resolution approaches of proteomics and miRNA transcriptomes to provide an integrated assessment. By using bioinformatics and systems biology, biological pathways and novel pathways involved in the response to IR exposure will be deciphered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- radiotherapy
- ionizing radiation
- proton radiotherapy
- pediatric oncology
- HARMONIC project
- congenital heart disease
- cardiac catheterization
- radiation biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Andreassi, Maria ...
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Haddy, Nadia
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Harms-Ringdahl, ...
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Campolo, Jonica
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Borghini, Andrea
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Chevalier, Franc ...
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Schwenk, Jochen ...
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Fresneau, Brice
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Bolle, Stephanie
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Fuentes, Manuel
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Haghdoost, Siama ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Kungliga Tekniska Högskolan
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Stockholms universitet