id:"swepub:oai:DiVA.org:kth-328100"
Search: id:"swepub:oai:DiVA.org:kth-328100" > Profiling spatiotem...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Li, XiaofeiKarolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden. (author)
Profiling spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- Springer Nature,2023
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-328100
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-328100URI
- https://doi.org/10.1038/s41593-023-01312-9DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:152591302URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523319URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20230602
- The authors created a comprehensive developmental cell atlas for spatiotemporal gene expression of the human spinal cord, revealed species-specific regulation during development and used the atlas to infer novel markers for pediatric ependymomas. The spatiotemporal regulation of cell fate specification in the human developing spinal cord remains largely unknown. In this study, by performing integrated analysis of single-cell and spatial multi-omics data, we used 16 prenatal human samples to create a comprehensive developmental cell atlas of the spinal cord during post-conceptional weeks 5-12. This revealed how the cell fate commitment of neural progenitor cells and their spatial positioning are spatiotemporally regulated by specific gene sets. We identified unique events in human spinal cord development relative to rodents, including earlier quiescence of active neural stem cells, differential regulation of cell differentiation and distinct spatiotemporal genetic regulation of cell fate choices. In addition, by integrating our atlas with pediatric ependymomas data, we identified specific molecular signatures and lineage-specific genes of cancer stem cells during progression. Thus, we delineate spatiotemporal genetic regulation of human spinal cord development and leverage these data to gain disease insight.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Andrusivova, ZanetaKTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u147zn3v (author)
- Czarnewski, PauloKTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Stockholm, Sweden.(Swepub:kth)u1mgo5fa (author)
- Langseth, Christoffer MattssonStockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden. (author)
- Andersson, AlmaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Genentech Inc, Dept Artificial Intelligence & Machine Learning, Res & Early Dev, South San Francisco, CA USA.(Swepub:kth)u15avt37 (author)
- Liu, YangKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China. (author)
- Gyllborg, DanielStockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden. (author)
- Braun, EmelieKarolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden. (author)
- Larsson, LudvigKTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u13lw4hm (author)
- Hu, LijuanKarolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden. (author)
- Alekseenko, ZhannaKarolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden. (author)
- Lee, HowerStockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden. (author)
- Avenel, ChristopheUppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen Vi3,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Informat Technol, Uppsala, Sweden.;SciLifeLab, BioImage Informat Facil, Sci Life Lab, Stockholm, Sweden.(Swepub:uu)chrav452 (author)
- Kallner, Helena KoppKarolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.;Danderyd Hosp, Dept Obstet & Gynecol, Danderyd, Sweden. (author)
- Akesson, ElisabetKarolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Stockholms Sjukhem, R&D Unit, Stockholm, Sweden. (author)
- Adameyko, IgorKarolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Med Univ Vienna, Ctr Brain Res, Dept Neuroimmunol, Vienna, Austria. (author)
- Nilsson, MatsStockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden. (author)
- Linnarsson, StenKarolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden. (author)
- Lundeberg, JoakimKTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u1qkn9kw (author)
- Sundstrom, ErikKarolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden. (author)
- Karolinska InstitutetKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden. (creator_code:org_t)
Related titles
- In:Nature Neuroscience: Springer Nature26:5, s. 891-9011097-62561546-1726
Internet link
- https://doi.org/10.1038/s41593-023-01312-9Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1839537/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-328100
- https://doi.org/10.1038/s41593-023-01312-9
- http://kipublications.ki.se/Default.aspx?queryparsed=id:152591302
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523319
Find in a library
- Nature Neuroscience (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Li, Xiaofei
- Andrusivova, Zan ...
- Czarnewski, Paul ...
- Langseth, Christ ...
- Andersson, Alma
- Liu, Yang
- show more...
- Gyllborg, Daniel
- Braun, Emelie
- Larsson, Ludvig
- Hu, Lijuan
- Alekseenko, Zhan ...
- Lee, Hower
- Avenel, Christop ...
- Kallner, Helena ...
- Akesson, Elisabe ...
- Adameyko, Igor
- Nilsson, Mats
- Linnarsson, Sten
- Lundeberg, Joaki ...
- Sundstrom, Erik
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Nature Neuroscie ...
- By the university
- Royal Institute of Technology
- Karolinska Institutet
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
