Search: id:"swepub:oai:DiVA.org:kth-328100" >
Profiling spatiotem...
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Li, XiaofeiKarolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
(author)
Profiling spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Springer Nature,2023
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-328100
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-328100URI
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https://doi.org/10.1038/s41593-023-01312-9DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152591302URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523319URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20230602
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The authors created a comprehensive developmental cell atlas for spatiotemporal gene expression of the human spinal cord, revealed species-specific regulation during development and used the atlas to infer novel markers for pediatric ependymomas. The spatiotemporal regulation of cell fate specification in the human developing spinal cord remains largely unknown. In this study, by performing integrated analysis of single-cell and spatial multi-omics data, we used 16 prenatal human samples to create a comprehensive developmental cell atlas of the spinal cord during post-conceptional weeks 5-12. This revealed how the cell fate commitment of neural progenitor cells and their spatial positioning are spatiotemporally regulated by specific gene sets. We identified unique events in human spinal cord development relative to rodents, including earlier quiescence of active neural stem cells, differential regulation of cell differentiation and distinct spatiotemporal genetic regulation of cell fate choices. In addition, by integrating our atlas with pediatric ependymomas data, we identified specific molecular signatures and lineage-specific genes of cancer stem cells during progression. Thus, we delineate spatiotemporal genetic regulation of human spinal cord development and leverage these data to gain disease insight.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Andrusivova, ZanetaKTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u147zn3v
(author)
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Czarnewski, PauloKTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Stockholm, Sweden.(Swepub:kth)u1mgo5fa
(author)
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Langseth, Christoffer MattssonStockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
(author)
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Andersson, AlmaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Genentech Inc, Dept Artificial Intelligence & Machine Learning, Res & Early Dev, South San Francisco, CA USA.(Swepub:kth)u15avt37
(author)
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Liu, YangKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China.
(author)
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Gyllborg, DanielStockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
(author)
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Braun, EmelieKarolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
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Larsson, LudvigKTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u13lw4hm
(author)
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Hu, LijuanKarolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
(author)
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Alekseenko, ZhannaKarolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden.
(author)
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Lee, HowerStockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
(author)
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Avenel, ChristopheUppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen Vi3,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Informat Technol, Uppsala, Sweden.;SciLifeLab, BioImage Informat Facil, Sci Life Lab, Stockholm, Sweden.(Swepub:uu)chrav452
(author)
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Kallner, Helena KoppKarolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.;Danderyd Hosp, Dept Obstet & Gynecol, Danderyd, Sweden.
(author)
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Akesson, ElisabetKarolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Stockholms Sjukhem, R&D Unit, Stockholm, Sweden.
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Adameyko, IgorKarolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Med Univ Vienna, Ctr Brain Res, Dept Neuroimmunol, Vienna, Austria.
(author)
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Nilsson, MatsStockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
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Linnarsson, StenKarolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
(author)
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Lundeberg, JoakimKTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u1qkn9kw
(author)
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Sundstrom, ErikKarolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
(author)
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Karolinska InstitutetKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
(creator_code:org_t)
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In:Nature Neuroscience: Springer Nature26:5, s. 891-9011097-62561546-1726
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Li, Xiaofei
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Andrusivova, Zan ...
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Czarnewski, Paul ...
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Langseth, Christ ...
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Andersson, Alma
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Liu, Yang
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Gyllborg, Daniel
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Braun, Emelie
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Larsson, Ludvig
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Hu, Lijuan
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Alekseenko, Zhan ...
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Lee, Hower
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Avenel, Christop ...
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Kallner, Helena ...
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Akesson, Elisabe ...
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Adameyko, Igor
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Nilsson, Mats
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Linnarsson, Sten
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Lundeberg, Joaki ...
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Sundstrom, Erik
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