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Multivalent Carbohy...
Multivalent Carbohydrate Nanocomposites for Tumor Microenvironment Remodeling to Enhance Antitumor Immunity
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- Hyun, Gyu Hwan (author)
- College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
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- Jeong, Da-Hye (author)
- Department of Biochemistry, Ajou University School of Medicine, Suwon 16499, Republic of Korea;Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea
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- Yang, Yoon Young (author)
- College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
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- Cho, In Ho (author)
- College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
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- Ha, Yu-Jin (author)
- Department of Biochemistry, Ajou University School of Medicine, Suwon 16499, Republic of Korea;Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea
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- Xing, Xiaohui (author)
- Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta T1J 4B1, Canada
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- Abbott, D. Wade (author)
- Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta T1J 4B1, Canada
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- Hsieh, Yves S. Y. (author)
- KTH,Glykovetenskap,School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
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- Kang, Yun Pyo (author)
- College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
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- Cha, Jong-Ho (author)
- Department of Biomedical Science, College of Medicine, and Program in Biomedical Sciences and Engineering, Inha University, Incheon 22332, Republic of Korea
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- Hong, Soon-Sun (author)
- Department of Biomedical Science, College of Medicine, and Program in Biomedical Sciences and Engineering, Inha University, Incheon 22332, Republic of Korea
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- Lee, Seul Ji (author)
- College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea;College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea
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- Kim, You-Sun (author)
- Department of Biochemistry, Ajou University School of Medicine, Suwon 16499, Republic of Korea;Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea
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- Kwon, Sung Won (author)
- College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
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(creator_code:org_t)
- American Chemical Society (ACS), 2023
- 2023
- English.
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In: ACS Nano. - : American Chemical Society (ACS). - 1936-0851 .- 1936-086X. ; 17:12, s. 11567-11582
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Current cancer immunotherapeutic strategies mainly focus on remodeling the tumor microenvironment (TME) to make it favorable for antitumor immunity. Increasing attention has been paid to developing innovative immunomodulatory adjuvants that can restore weakened antitumor immunity by conferring immunogenicity to inflamed tumor tissues. Here, a galactan-enriched nanocomposite (Gal-NC) is developed from native carbohydrate structures through an optimized enzymatic transformation for effective, stable, and biosafe innate immunomodulation. Gal-NC is characterized as a carbohydrate nanoadjuvant with a macrophage-targeting feature. It is composed of repeating galactan glycopatterns derived from heteropolysaccharide structures of plant origin. The galactan repeats of Gal-NC function as multivalent pattern-recognition sites for Toll-like receptor 4 (TLR4). Functionally, Gal-NC-mediated TLR activation induces the repolarization of tumor-associated macrophages (TAMs) toward immunostimulatory/tumoricidal M1-like phenotypes. Gal-NC increases the intratumoral population of cytotoxic T cells, the main effector cells of antitumor immunity, via re-educated TAMs. These TME alterations synergistically enhance the T-cell-mediated antitumor response induced by αPD-1 administration, suggesting that Gal-NC has potential value as an adjuvant for immune checkpoint blockade combination therapies. Thus, the Gal-NC model established herein suggests a glycoengineering strategy to design a carbohydrate-based nanocomposite for advanced cancer immunotherapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
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ACS Nano
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- By the author/editor
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Hyun, Gyu Hwan
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Jeong, Da-Hye
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Yang, Yoon Young
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Cho, In Ho
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Ha, Yu-Jin
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Xing, Xiaohui
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Abbott, D. Wade
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Hsieh, Yves S. Y ...
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Kang, Yun Pyo
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Cha, Jong-Ho
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Hong, Soon-Sun
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Lee, Seul Ji
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Kim, You-Sun
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Kwon, Sung Won
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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ACS Nano
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Royal Institute of Technology