Electrohydraulic Vascular Compression Device (e-VaC) with Integrated Sensing and Controls

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MARC

Pirozzi, I. (author)

Electrohydraulic Vascular Compression Device (e-VaC) with Integrated Sensing and Controls

Article/chapterEnglish2023

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2022-11-13
Wiley,2023
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LIBRIS-ID:oai:DiVA.org:kth-329003
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-329003URI
https://doi.org/10.1002/admt.202201196DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

QC 20230614
Right ventricular (RV) failure remains a significant clinical burden particularly during the perioperative period surrounding major cardiac surgeries, such as implantation of left ventricular assist devices (LVADs), bypass procedures or valvular surgeries. Device solutions designed to support the function of the RV do not keep up with the pace of development of left-sided solutions, leaving the RV vulnerable to acute failure in the challenging hemodynamic environments of the perioperative setting. This work describes the design of a biomimetic, soft, conformable sleeve that can be prophylactically implanted on the pulmonary artery to support RV ventricular function during major cardiac surgeries, through afterload reduction and augmentation of flow. Leveraging electrohydraulic principles, a technology is proposed that is non-blood contacting and obviates the necessity for drivelines by virtue of being electrically powered. In addition, the integration of an adjacent is demonstrate, continuous pressure sensing module to support physiologically adaptive control schemes based on a real-time biological signal. In vitro experiments conducted in a pulsatile flow-loop replicating physiological flow and pressure conditions show a reduction of mean pulmonary arterial pressure of 8 mmHg (25% reduction), a reduction in peak systolic arterial pressure of up to 10 mmHg (20% reduction), and a concomitant 19% increase in diastolic pulmonary flow. Computational simulations further predict substantial augmentation of cardiac output as a result of reduced RV ventricular stress and RV dilatation.

Subject headings and genre

TEKNIK OCH TEKNOLOGIER Medicinteknik hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering hsv//eng
continuous sensing
electrohydraulic actuator
mechanical cardiac support
right ventricular failure
Artificial heart
Biomimetics
Cardiovascular surgery
Failure (mechanical)
Heart
Hydraulic actuators
Left ventricular assist devices
Mechanical actuators
% reductions
Cardiac-surgery
Compression devices
Electro-hydraulic actuator
Electro-hydraulics
Mechanical
Right ventricular
Hydraulics

Added entries (persons, corporate bodies, meetings, titles ...)

Kight, A. (author)
Liang, X. (author)
Han, A. K. (author)
Ennis, D. B. (author)
Hiesinger, W. (author)
Dual, Seraina A.KTH,Medicinteknik och hälsosystem(Swepub:kth)u1zh79lk (author)
Cutkosky, M. R. (author)
KTHMedicinteknik och hälsosystem (creator_code:org_t)

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In:Advanced Materials Technologies: Wiley8:4, s. 2201196-2365-709X

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By the author/editor: Pirozzi, I.; Kight, A.; Liang, X.; Han, A. K.; Ennis, D. B.; Hiesinger, W.; show more...; Dual, Seraina A.; Cutkosky, M. R.; show less...

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ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Medical Engineer ...

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By the university: Royal Institute of Technology

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