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  • Battisti, Umberto MariaGothenburg University,Göteborgs universitet,KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab,Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)

Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • MDPI AG,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-329870
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-329870URI
  • https://doi.org/10.3390/ph16050668DOI
  • https://gup.ub.gu.se/publication/327965URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20230626
  • The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis. Recently, urolithin C has been reported as a new scaffold for the development of allosteric inhibitors of liver pyruvate kinase (PKL). In this work, a comprehensive structure-activity analysis of urolithin C was carried out. More than 50 analogues were synthesized and tested regarding the chemical features responsible for the desired activity. These data could pave the way to the development of more potent and selective PKL allosteric inhibitors.

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  • Monjas, LeticiaGothenburg University,Göteborgs universitet,KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:kth)u1s83a64 (author)
  • Akladios, FadyGothenburg University,Göteborgs universitet,KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab,Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:kth)u15nddk1 (author)
  • Matic, JosipaGothenburg University,Göteborgs universitet,KTH,Science for Life Laboratory, SciLifeLab,Skolan för kemi, bioteknologi och hälsa (CBH),Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:kth)PI000000 (author)
  • Andresen, EricGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)
  • Nagel, Carolin H.Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)
  • Hagkvist, MalinGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)
  • Håversen, Liliana,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xhavli (author)
  • Kim, WoongheeKTH,Systembiologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1nic2pk (author)
  • Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi(Swepub:kth)u1dulvmw (author)
  • Borén, Jan,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xborej (author)
  • Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.(Swepub:kth)u1t8kmr6 (author)
  • Grötli, MortenGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xgromo (author)
  • KTHNanobioteknologi (creator_code:org_t)

Related titles

  • In:Pharmaceuticals: MDPI AG16:51424-8247

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