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Sökning: id:"swepub:oai:DiVA.org:kth-331483" > Elevated plasma com...

  • Iglesias, Maria JesusKTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Division of Internal Medicine, University Hospital of North Norway (UNN), PB100, 9038, Tromsø, Norway; Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway (författare)

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Springer Nature,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-331483
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-331483URI
  • https://doi.org/10.1038/s41467-023-38383-yDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154332493URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Correction in: Nature Communications, vol. 14, issue 1. DOI:10.1038/s41467-023-43764-4QC 20231214
  • Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sanchez-Rivera, LauraKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u13bwsp9 (författare)
  • Ibrahim-Kosta, ManalAix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France, HemoVasc (CRB AP-HM HemoVasc) (författare)
  • Naudin, ClémentKTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway(Swepub:kth)u1jrpmuu (författare)
  • Munsch, GaëlleUniversity of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, ELEANOR, Bordeaux, France, ELEANOR (författare)
  • Goumidi, LouisaAix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France, HemoVasc (CRB AP-HM HemoVasc) (författare)
  • Farm, MariaKarolinska Institutet (författare)
  • Smith, Philip M.Karolinska Institutet (författare)
  • Thibord, FlorianPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, USA; The Framingham Heart Study, Boston University, Framingham, MA, USA (författare)
  • Kral-Pointner, Julia BarbaraCenter for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria (författare)
  • Hong, Mun-GwanKTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u19gmsru (författare)
  • Suchon, PierreAix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France, HemoVasc (CRB AP-HM HemoVasc) (författare)
  • Germain, MarineUniversity of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, ELEANOR, Bordeaux, France, ELEANOR; Laboratory of Excellence GENMED (Medical Genomics), Bordeaux, France (författare)
  • Schottmaier, WaltraudCenter for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria (författare)
  • Dusart, PhilipKTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway(Swepub:kth)u13mq3yk (författare)
  • Boland, AnneUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France; Laboratory of Excellence GENMED (Medical Genomics), Evry, France (författare)
  • Kotol, DavidKTH,Systembiologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1yd1hdh (författare)
  • Edfors, FredrikKTH,Science for Life Laboratory, SciLifeLab,Systembiologi(Swepub:kth)u149ml0e (författare)
  • Koprulu, MineMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK (författare)
  • Pietzner, MaikMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK (författare)
  • Langenberg, ClaudiaMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK (författare)
  • Damrauer, Scott M.Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA; Department of Surgery and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (författare)
  • Johnson, Andrew D.Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, USA; The Framingham Heart Study, Boston University, Framingham, MA, USA (författare)
  • Klarin, Derek M.VA Palo Alto Healthcare System, Palo Alto, CA, USA; Department of Vascular Surgery, Stanford University School of Medicine, Palo Alto, CA, USA (författare)
  • Smith, Nicholas L.Department of Epidemiology, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA (författare)
  • Smadja, David M.Hematology Department and Biosurgical Research Lab (Carpentier Foundation), European Georges Pompidou Hospital, Assistance Publique Hôpitaux de Paris, 20 rue Leblanc, Paris, 75015, France, 20 rue Leblanc; Innovative Therapies in Haemostasis, INSERM, Université de Paris, 4 avenue de l’Observatoire, Paris, 75270, France, 4 avenue de l’Observatoire (författare)
  • Holmström, MargaretaCoagulation Unit, Department of Haematology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden, SE-171 76 (författare)
  • Magnusson, MariaDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; Coagulation Unit, Department of Haematology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden, SE-171 76; Department of Clinical Science, Intervention and Technology, Karolinska Institute, 171 77, Stockholm, Sweden, 171 77 (författare)
  • Silveira, AngelaKarolinska Institutet (författare)
  • Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi(Swepub:kth)u1dulvmw (författare)
  • Renné, ThomasInstitute for Clinical Chemistry and Laboratory Medicine, University Medical Centre Hamburg-Eppendorf, D-20246, Hamburg, Germany; Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, D-, 55131, Mainz, Germany; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, D02 YN77, Ireland (författare)
  • Martinez-Perez, AngelGenomics of Complex Diseases Group, Research Institute Hospital de la Santa Creu i Sant Pau. IIB Sant Pau, Barcelona, Spain (författare)
  • Emmerich, JosephDepartment of vascular medicine, Paris Saint-Joseph Hospital Group, INSERM 1153-CRESS, University of Paris Cité, 185 rue Raymond Losserand, Paris, 75674, France, 185 rue Raymond Losserand (författare)
  • Deleuze, Jean FrancoisUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France; Laboratory of Excellence GENMED (Medical Genomics), Evry, France; Centre D’Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France (författare)
  • Antovic, JovanKarolinska Institutet (författare)
  • Soria Fernandez, Jose ManuelGenomics of Complex Diseases Group, Research Institute Hospital de la Santa Creu i Sant Pau. IIB Sant Pau, Barcelona, Spain (författare)
  • Assinger, AliceCenter for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria (författare)
  • Schwenk, Jochen M.KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1h7wtme (författare)
  • Souto Andres, Joan CarlesUnitat d’Hemostàsia i Trombosi. Hospital de la Santa Creu i Sant Pau and IIB-Sant Pau, Barcelona, Spain (författare)
  • Morange, Pierre EmmanuelAix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France, HemoVasc (CRB AP-HM HemoVasc) (författare)
  • Butler, Lynn M.KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden(Swepub:kth)u1tkjrxa (författare)
  • Trégouët, David AlexandreUniversity of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, ELEANOR, Bordeaux, France, ELEANOR; Laboratory of Excellence GENMED (Medical Genomics), Bordeaux, France (författare)
  • Odeberg, Jacob,Professor,1963-KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Division of Internal Medicine, University Hospital of North Norway (UNN), PB100, 9038, Tromsø, Norway; Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway; Department of Medicine Solna, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden; Coagulation Unit, Department of Haematology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden, SE-171 76(Swepub:kth)u1e4yljo (författare)
  • KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Communications: Springer Nature14:12041-1723

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