Sökning: WFRF:(Williams Cecilia Professor 1969 ) >
ERβ in Granulosa Ce...
ERβ in Granulosa Cell Tumors and Its Clinical Potential
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- Birgersson, Madeleine (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
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- Indukuri, Rajitha (författare)
- KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab
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- Antonson, Per (författare)
- Karolinska Institutet
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- Nalvarte, Ivan (författare)
- Karolinska Institutet
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- Archer, Amena (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
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- Williams, Cecilia, Professor, 1969- (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
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(creator_code:org_t)
- The Endocrine Society, 2023
- 2023
- Engelska.
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Ingår i: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 164:6
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCTs, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ERβ/ESR2) has been found to be highly expressed in GCTs, which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCTs is not known. In this review, we summarize the current knowledge about the action of ERβ in the ovary and discuss its prospective role in GCTs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- estrogen receptor beta
- fertility
- granulosa cell tumor
- knockout mouse model
- ovary
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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