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Sökning: L773:1369 3786 OR L773:1460 2709 > Antifungal activity...

  • de Oliveira, Andressa SouzaUniv Brasilia, Fac Med, Trop Med Ctr, Lab Dev Therapeut Innovat, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Univ Brasilia, Fac Hlth Sci, Postgrad Program Pharmaceut Sci, Asa Norte, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil. (författare)

Antifungal activity of sustainable histone deacetylase inhibitors against planktonic cells and biofilms of Candida spp. and Cryptococcusneoformans

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Oxford University Press (OUP),2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-334763
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-334763URI
  • https://doi.org/10.1093/mmy/myad073DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20230824
  • The limited therapeutic options for fungal infections and the increased incidence of fungal strains resistant to antifungal drugs, especially Candida spp., require the development of new antifungal drugs and strategies. Histone deacetylase inhibitors (HDACi), like vorinostat, have been studied in cancer treatment and have antifungal effects, acting alone or synergistically with classical antifungals. Here we investigated the antifungal activity of two novel sustainable HDACi (LDT compounds) based on vorinostat structure. Molecular docking simulation studies reveal that LDT compounds can bind to Class-I HDACs of Candida albicans, C. tropicalis, and Cryptococcus neoformans, which showed similar binding mode to vorinostat. LDT compounds showed moderate activity when tested alone against fungi but act synergistically with antifungal azoles against Candida spp. They reduced biofilm formation by more than 50% in C. albicans (4 µg/mL), with the main action in fungal filamentation. Cytotoxicity of the LDT compounds against RAW264.7 cells was evaluated and LDT536 demonstrated cytotoxicity only at the concentration of 200 µmol/L, while LDT537 showed IC50 values of 29.12 µmol/L. Our data indicated that these sustainable and inexpensive HDACi have potential antifungal and antibiofilm activities, with better results than vorinostat, although further studies are necessary to better understand the mechanism against fungal cells.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • de Oliveira, Jonathas SalesUniv Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (författare)
  • Kumar, RajenderKTH,Glykovetenskap(Swepub:kth)u1gvg2bt (författare)
  • Silva, Fabiana Brandao AlvesUniv Brasilia, Fac Med, Postgrad Program Trop Med, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil. (författare)
  • Fernandes, Mirele RodriguesUniv Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (författare)
  • Nobre, Feynman DiasUniv Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (författare)
  • Costa, Anderson da CunhaUniv Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (författare)
  • Albuquerque, PatriciaUniv Brasilia, Ctr Metropolitano Conjunto, Campus Ceilandia,Lote 01, BR-72220900 Brasilia, DF, Brazil. (författare)
  • Sidrim, Jose Julio CostaUniv Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (författare)
  • Rocha, Marcos Fabio GadelhaUniv Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (författare)
  • Santos, Flavia AlmeidaUniv Fed Ceara, Dept Physiol & Pharmacol, Lab Nat Prod, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (författare)
  • Srivastava, VaibhavKTH,Glykovetenskap(Swepub:kth)u11h450n (författare)
  • Romeiro, Luiz Antonio SoaresUniv Brasilia, Fac Med, Trop Med Ctr, Lab Dev Therapeut Innovat, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Univ Brasilia, Fac Hlth Sci, Postgrad Program Pharmaceut Sci, Asa Norte, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Univ Brasilia, Fac Med, Postgrad Program Trop Med, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil. (författare)
  • Brilhante, Raimunda Samia NogueiraUniv Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil.;Rua Coronel Nunes Melo 1315, BR-60420270 Fortaleza, CE, Brazil. (författare)
  • Univ Brasilia, Fac Med, Trop Med Ctr, Lab Dev Therapeut Innovat, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.;Univ Brasilia, Fac Hlth Sci, Postgrad Program Pharmaceut Sci, Asa Norte, Campus Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil.Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes Melo 1315, BR-60430275 Fortaleza, CE, Brazil. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Medical Mycology: Oxford University Press (OUP)61:81369-37861460-2709

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