Mesoporous silica particles are phagocytosed by microglia and induce a mild inflammatory response in vitro

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Abrahamsson Ninnie) > Mesoporous silica p...

Mesoporous silica particles are phagocytosed by microglia and induce a mild inflammatory response in vitro

Sala-Jarque, Júlia (författare): Biochemistry and Molecular Biology Unit, Department of Biomedical Sciences, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia,Univ Barcelona, Sch Med, Inst Invest Biomed August Pi & Sunyer, Dept Biomed Sci,Biochem & Mol Biol Unit, Barcelona, Catalonia, Spain.

García-Lara, Elisa (författare): Biochemistry and Molecular Biology Unit, Department of Biomedical Sciences, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia,Univ Barcelona, Sch Med, Inst Invest Biomed August Pi & Sunyer, Dept Biomed Sci,Biochem & Mol Biol Unit, Barcelona, Catalonia, Spain.

Carreras-Domínguez, Paula (författare): Biochemistry and Molecular Biology Unit, Department of Biomedical Sciences, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia,Univ Barcelona, Sch Med, Inst Invest Biomed August Pi & Sunyer, Dept Biomed Sci,Biochem & Mol Biol Unit, Barcelona, Catalonia, Spain.

visa fler...

Zhou, Chunfang (författare): Nanologica AB, Södertälje, Sweden.

Rabaneda-Lombarte, Neus (författare): Biochemistry and Molecular Biology Unit, Department of Biomedical Sciences, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia; Department of Cerebral Ischemia and Neurodegeneration, Instituto de Investigaciones Biomédicas de Barcelona, Consejo Superior de Investigaciones Científicas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia,Univ Barcelona, Sch Med, Inst Invest Biomed August Pi & Sunyer, Dept Biomed Sci,Biochem & Mol Biol Unit, Barcelona, Catalonia, Spain.;Inst Invest Biomed August Pi & Sunyer, Inst Invest Biomed Barcelona, Dept Cerebral Ischemia & Neurodegenerat, CSIC, Barcelona, Catalonia, Spain.

Solà, Carme (författare): Department of Cerebral Ischemia and Neurodegeneration, Instituto de Investigaciones Biomédicas de Barcelona, Consejo Superior de Investigaciones Científicas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia,Inst Invest Biomed August Pi & Sunyer, Inst Invest Biomed Barcelona, Dept Cerebral Ischemia & Neurodegenerat, CSIC, Barcelona, Catalonia, Spain.

M Vidal-Taboada, Jose (författare): Biochemistry and Molecular Biology Unit, Department of Biomedical Sciences, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia; Peripheral Nervous System, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Barcelona, Catalonia, Spain, Catalonia,Univ Barcelona, Sch Med, Inst Invest Biomed August Pi & Sunyer, Dept Biomed Sci,Biochem & Mol Biol Unit, Barcelona, Catalonia, Spain.;Vall dHebron Hosp Univ, Vall dHebron Inst Recerca, Peripheral Nervous Syst, Barcelona, Catalonia, Spain.

Feiler, Adam (författare): KTH,Yt- och korrosionsvetenskap,Nanologica AB, Södertälje, Sweden.;KTH Royal Inst Technol, Stockholm, Sweden.

Abrahamsson, Ninnie (författare): Uppsala universitet,Institutionen för immunologi, genetik och patologi

Kozlova, Elena (författare): Uppsala universitet,Genomik och neurobiologi

Saura, Josep (författare): Biochemistry and Molecular Biology Unit, Department of Biomedical Sciences, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia; Institute of Neurosciences, University of Barcelona, Catalonia, Spain,Univ Barcelona, Sch Med, Inst Invest Biomed August Pi & Sunyer, Dept Biomed Sci,Biochem & Mol Biol Unit, Barcelona, Catalonia, Spain.;Univ Barcelona, Inst Neurosci, Barcelona, Catalonia, Spain.

visa färre...

Biochemistry and Molecular Biology Unit, Department of Biomedical Sciences, School of Medicine, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain, Catalonia Univ Barcelona, Sch Med, Inst Invest Biomed August Pi & Sunyer, Dept Biomed Sci,Biochem & Mol Biol Unit, Barcelona, Catalonia, Spain (creator_code:org_t)

Future Medicine Ltd, 2022
2022
Engelska.
Ingår i: Nanomedicine. - : Future Medicine Ltd. - 1743-5889 .- 1748-6963. ; 17:15, s. 1077-1094

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.2...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Aim:Mesoporous silica particles (MSPs) are broadly used drug delivery carriers. In this study, the authors analyzed the responses to MSPs of astrocytes and microglia, the two main cellular players in neuroinflammation.Materials & methods:Primary murine cortical mixed glial cultures were treated with rhodamine B-labeled MSPs.Results:MSPs are avidly internalized by microglial cells and remain inside the cells for at least 14 days. Despite this, MSPs do not affect glial cell viability or morphology, basal metabolic activity or oxidative stress. MSPs also do not affect mRNA levels of key proinflammatory genes; however, in combination with lipopolysaccharide, they significantly increase extracellular IL-1β levels.Conclusion:These results suggest that MSPs could be novel tools for specific drug delivery to microglial cells. Plain language summary Mesoporous silica particles (MSPs) are broadly used drug delivery carriers. In this study, the authors analyzed the responses of two types of brain cells, astrocytes and microglia, to MSPs. Mouse astrocytes and microglia were kept alive in cultures and were treated with MSPs that were labeled with a red fluorescent agent to facilitate visualization under the microscope. MSPs are avidly internalized by microglial cells and remain inside the cells for at least 14 days. Despite this, MSPs do not affect glial cell viability or morphology, basal metabolic activity or oxidative stress. When given alone, MSPs do not affect mRNA levels of key proinflammatory genes. However, MSPs given in combination with lipopolysaccharide, a strong proinflammatory agent, significantly increase extracellular levels of IL-1β, one of the proinflammatory mediators studied. These results suggest that MSPs could be novel tools for specific drug delivery to microglial cells.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

astrocytes
mesoporous silica particles
microglia
neuroinflammation

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Nanomedicine (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Sala-Jarque, Júl ...; García-Lara, Eli ...; Carreras-Domíngu ...; Zhou, Chunfang; Rabaneda-Lombart ...; Solà, Carme; visa fler...; M Vidal-Taboada, ...; Feiler, Adam; Abrahamsson, Nin ...; Kozlova, Elena; Saura, Josep; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmakologi och ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Artiklar i publikationen: Nanomedicine

Av lärosätet: Kungliga Tekniska Högskolan; Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se