Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis

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Sökning: WFRF:(Jochen R) > (2020-2024) > Application of clin...

FitzGerald, OliverUniv Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Sch Med, Dublin, Ireland. (författare)

Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis

Artikel/kapitelEngelska2023

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SAGE PUBLICATIONS LTD,2023
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LIBRIS-ID:oai:DiVA.org:kth-337030
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-337030URI
https://doi.org/10.1177/1759720X231192315DOI

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Språk:engelska
Sammanfattning på:engelska

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QC 20230922
Achieving a good outcome for a person with Psoriatic Arthritis (PsA) is made difficult by late diagnosis, heterogenous clinical disease expression and in many cases, failure to adequately suppress inflammatory disease features. Single-centre studies have certainly contributed to our understanding of disease pathogenesis, but to adequately address the major areas of unmet need, multi-partner, collaborative research programmes are now required. HIPPOCRATES is a 5-year, Innovative Medicines Initiative (IMI) programme which includes 17 European academic centres experienced in PsA research, 5 pharmaceutical industry partners, 3 small-/medium-sized industry partners and 2 patient-representative organizations. In this review, the ambitious programme of work to be undertaken by HIPPOCRATES is outlined and common approaches and challenges are identified. It is expected that, when completed, the results will ultimately allow for changes in the approaches to diagnosing, managing and treating PsA allowing for better short-term and long-term outcomes. Improving outcomes in Psoriatic ArthritisPsoriatic Arthritis (PsA) is a form of arthritis which is found in approximately 30% of people who have the skin condition, Psoriasis. Frequently debilitating and progressive, achieving a good outcome for a person with PsA is made difficult by late diagnosis, disease clinical features and in many cases, failure to adequately control features of inflammation. Research studies from individual centres have certainly contributed to our understanding of why people develop PsA but to adequately address the major areas of unmet need, multi-centre, collaborative research programmes are now required. HIPPOCRATES is a 5-year, Innovative Medicines Initiative (IMI) programme which includes 17 European academic centres experienced in PsA research, 5 pharmaceutical industry partners, 3 small-/medium-sized industry partners and 2 patient representative organisations (see appendix). In this review, the ambitious programme of work to be undertaken by HIPPOCRATES is outlined and common approaches and challenges are identified. The participation of patient research partners in all stages of the work of HIPPOCRATES is highlighted. It is expected that, when completed, the results will ultimately allow for changes in the approaches to diagnosing, managing and treating PsA allowing for improvements in short-term and long-term outcomes.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
diagnosis
HIPPOCRATES
IMI
multi-omics
psoriasis
psoriatic arthritis
patient outcomes

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Schwenk, Jochen M.KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1h7wtme (författare)
Consortium, H I P P O C R A T E S (författare)
Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Sch Med, Dublin, Ireland.Science for Life Laboratory, SciLifeLab (creator_code:org_t)

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Ingår i:Therapeutic Advances in Musculoskeletal Disease: SAGE PUBLICATIONS LTD151759-72181759-720X

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