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A topographic atlas...
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
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- Sountoulidis, Alexandros (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Sci Life Lab, Solna, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Marco Salas, Sergio (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik,Sci Life Lab, Solna, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.
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- Braun, Emelie (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
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- Avenel, Christophe (author)
- Uppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen Vi3,Science for Life Laboratory, SciLifeLab
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- Bergenstråhle, Joseph (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Theelke, Jonas, 1994- (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Sci Life Lab, Solna, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Vicari, Marco (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Czarnewski, Paulo (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Liontos, Andreas (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Sci Life Lab, Solna, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Abalo, Xesús M (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Andrusivova, Zaneta (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Mirzazadeh, Reza (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Asp, Michaela (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Li, Xiaofei (author)
- Karolinska Institutet,Care Sci & Soc, Karolinska Inst, Dept Neurobiol, Stockholm, Sweden.
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- Hu, Lijuan (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
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- Sariyar, Sanem (author)
- Karolinska Institutet,KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Royal Inst Technol, Sch Engn Sci Chem, Sci Life Lab, Biotechnol & Hlth, Stockholm, Sweden.
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- Martinez Casals, Ana (author)
- KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Royal Inst Technol, Sch Engn Sci Chem, Sci Life Lab, Biotechnol & Hlth, Stockholm, Sweden.
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- Ayoglu, Burcu (author)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Royal Inst Technol, Sch Engn Sci Chem, Sci Life Lab, Biotechnol & Hlth, Stockholm, Sweden.
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- Firsova, Alexandra (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Sci Life Lab, Solna, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Michaelsson, Jakob (author)
- Karolinska Institutet,Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden.
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- Lundberg, Emma (author)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Royal Inst Technol, Sch Engn Sci Chem, Sci Life Lab, Biotechnol & Hlth, Stockholm, Sweden.
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- Wählby, Carolina, professor, 1974- (author)
- Uppsala universitet,Bildanalys och människa-datorinteraktion,Science for Life Laboratory, SciLifeLab,Avdelningen Vi3
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- Sundstroem, Erik (author)
- Karolinska Institutet,Care Sci & Soc, Karolinska Inst, Dept Neurobiol, Stockholm, Sweden.
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- Linnarsson, Sten (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
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- Lundeberg, Joakim (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Nilsson, Mats (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Sci Life Lab, Solna, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.
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- Samakovlis, Christos (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Sci Life Lab, Solna, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.;Justus Liebig Univ, Cardiopulm Inst, Mol Pneumol, Giessen, Germany.
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(creator_code:org_t)
- 2023-01-16
- 2023
- English.
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In: Nature Cell Biology. - : Springer Nature. - 1465-7392 .- 1476-4679.
- Related links:
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Abstract
Subject headings
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- Sountoulidis et al. provide a spatial gene expression atlas of human embryonic lung during the first trimester of gestation and identify 83 cell identities corresponding to stable cell types or transitional states. The lung contains numerous specialized cell types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a comprehensive topographic atlas of early human lung development. Here we report 83 cell states and several spatially resolved developmental trajectories and predict cell interactions within defined tissue niches. We integrated single-cell RNA sequencing and spatially resolved transcriptomics into a web-based, open platform for interactive exploration. We show distinct gene expression programmes, accompanying sequential events of cell differentiation and maturation of the secretory and neuroendocrine cell types in proximal epithelium. We define the origin of airway fibroblasts associated with airway smooth muscle in bronchovascular bundles and describe a trajectory of Schwann cell progenitors to intrinsic parasympathetic neurons controlling bronchoconstriction. Our atlas provides a rich resource for further research and a reference for defining deviations from homeostatic and repair mechanisms leading to pulmonary diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sountoulidis, Al ...
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Marco Salas, Ser ...
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Braun, Emelie
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Avenel, Christop ...
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Bergenstråhle, ...
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Theelke, Jonas, ...
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show more...
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Vicari, Marco
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Czarnewski, Paul ...
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Liontos, Andreas
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Abalo, Xesús M
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Andrusivova, Zan ...
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Mirzazadeh, Reza
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Asp, Michaela
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Li, Xiaofei
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Hu, Lijuan
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Sariyar, Sanem
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Martinez Casals, ...
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Ayoglu, Burcu
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Firsova, Alexand ...
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Michaelsson, Jak ...
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Lundberg, Emma
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Wählby, Carolina ...
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Sundstroem, Erik
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Linnarsson, Sten
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Lundeberg, Joaki ...
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Nilsson, Mats
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Samakovlis, Chri ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Nature Cell Biol ...
- By the university
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Royal Institute of Technology
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Stockholm University
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Karolinska Institutet
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Uppsala University