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  • Mescia, FedericaDepartment of Medicine, University of Cambridge, Cambridge CB2 0SP, UK;; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, CB2 0AW, UK, Cambridge Biomedical Campus; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, Italy (författare)

Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • MDPI AG,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-339517
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-339517URI
  • https://doi.org/10.3390/ijms242015341DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20231114
  • ANCA-associated vasculitides (AAV) are rare autoimmune diseases causing inflammation and damage to small blood vessels. New autoantibody biomarkers are needed to improve the diagnosis and treatment of AAV patients. In this study, we aimed to profile the autoantibody repertoire of AAV patients using in-house developed antigen arrays to identify previously unreported antibodies linked to the disease per se, clinical subgroups, or clinical activity. A total of 1743 protein fragments representing 1561 unique proteins were screened in 229 serum samples collected from 137 AAV patients at presentation, remission, and relapse. Additionally, serum samples from healthy individuals and patients with other type of vasculitis and autoimmune-inflammatory conditions were included to evaluate the specificity of the autoantibodies identified in AAV. Autoreactivity against members of the kinesin protein family were identified in AAV patients, healthy volunteers, and disease controls. Anti-KIF4A antibodies were significantly more prevalent in AAV. We also observed possible associations between anti-kinesin antibodies and clinically relevant features within AAV patients. Further verification studies will be needed to confirm these findings.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bayati, ShaghayeghKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1n22avk (författare)
  • Brouwer, ElisabethDepartment of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, The Netherlands (författare)
  • Heeringa, PeterDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands; (författare)
  • Toonen, Erik J.M.R&D Department, Hycult Biotech, Uden, 5405 PB, The Netherlands (författare)
  • Beenes, MarijkeR&D Department, Hycult Biotech, Uden, 5405 PB, The Netherlands (författare)
  • Ball, Miriam J.Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria; (författare)
  • Rees, Andrew J.Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria; (författare)
  • Kain, RenateDepartment of Pathology, Medical University of Vienna, 1090 Vienna, Austria; (författare)
  • Lyons, Paul A.Department of Medicine, University of Cambridge, Cambridge CB2 0SP, UK;; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, CB2 0AW, UK, Cambridge Biomedical Campus (författare)
  • Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1ws88sk (författare)
  • Pin, ElisaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1pmjyje (författare)
  • Department of Medicine, University of Cambridge, Cambridge CB2 0SP, UK;; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, CB2 0AW, UK, Cambridge Biomedical Campus; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, ItalyAffinitets-proteomik (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Molecular Sciences: MDPI AG24:201661-65961422-0067

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