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The impact of Parki...
The impact of Parkinson’s disease on striatal network connectivity and cortico-striatal drive : an in-silico study
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- Carannante, Ilaria (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST),Science for Life Laboratory, SciLifeLab
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- Scolamiero, Martina, 1986- (author)
- KTH,Matematik för Data och AI
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Hjorth, J. J. Johannes (author)
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- Kozlov, Alexander (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST),Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Bekkouche, Bo (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST)
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- Guo, Lihao (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST)
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- Kumar, Arvind (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST)
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- Chachólski, Wojciech (author)
- KTH,Matematik (Avd.)
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- Hellgren Kotaleski, Jeanette (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST),Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- English.
- Related links:
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https://doi.org/10.1...
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https://www.biorxiv....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Striatum, the input stage of the basal ganglia, is important for sensory-motor integration, initiation and selection of behaviour, as well as reward learning. Striatum receives glutamatergic inputs from mainly cortex and thalamus. In rodents, the striatal projection neurons (SPNs), giving rise to the direct and the indirect pathway (dSPNs and iSPNs, respectively), account for 95% of the neurons and the remaining 5% are GABAergic and cholinergic interneurons. Interneuron axon terminals as well as local dSPN and iSPN axon collaterals form an intricate striatal network. Following chronic dopamine depletion as in Parkinson’s disease (PD), both morphological and electrophysiological striatal neuronal features are altered. Our goal with this \textit{in-silico} study is twofold: a) to predict and quantify how the intrastriatal network connectivity structure becomes altered as a consequence of the morphological changes reported at the single neuron level, and b) to investigate how the effective glutamatergic drive to the SPNs would need to be altered to account for the activity level seen in SPNs during PD. In summary we find that the richness of the connectivity motifs is significantly decreased during PD, while at the same time a substantial enhancement of the effective glutamatergic drive to striatum is present.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Parkinson’s disease
- Striatum
- Computational modeling
- Topological data analysis
- Directed cliques
- Network higher order connectivity
- Neuronal degeneration model
- Datalogi
- Computer Science
- Tillämpad matematik och beräkningsmatematik
- Applied and Computational Mathematics
Publication and Content Type
- vet (subject category)
- ovr (subject category)
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