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  • Mälarstig, AndersPfizer Worldwide Res Dev & Med, Stockholm, Sweden (author)

Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Springer Nature,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-340831
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-340831URI
  • https://doi.org/10.1038/s41467-023-43485-8DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519045URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154329381URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20231218
  • Biomarkers for early detection of breast cancer may complement population screening approaches to enable earlier and more precise treatment. The blood proteome is an important source for biomarker discovery but so far, few proteins have been identified with breast cancer risk. Here, we measure 2929 unique proteins in plasma from 598 women selected from the Karolinska Mammography Project to explore the association between protein levels, clinical characteristics, and gene variants, and to identify proteins with a causal role in breast cancer. We present 812 cis-acting protein quantitative trait loci for 737 proteins which are used as instruments in Mendelian randomisation analyses of breast cancer risk. Of those, we present five proteins (CD160, DNPH1, LAYN, LRRC37A2 and TLR1) that show a potential causal role in breast cancer risk with confirmatory results in independent cohorts. Our study suggests that these proteins should be further explored as biomarkers and potential drug targets in breast cancer.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Grassmann, FelixKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; Hlth & Med Univ, Inst Clin Res & Syst Med, Potsdam, Germany (author)
  • Dahl, Leo,1995-KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1sl47pr (author)
  • Dimitriou, MariosKarolinska Institutet (author)
  • McLeod, DiannaKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
  • Gabrielson, MarikeKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
  • Smith-Byrne, KarlUniv Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England (author)
  • Thomas, Cecilia EngelKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ja1scu (author)
  • Huang, Tzu HsuanPfizer Inc, Canc Immunol Discovery, San Diego, CA USA (author)
  • Forsberg, Simon K.G.Olink Prote AB, Uppsala, Sweden (author)
  • Eriksson, PerOlink Prote AB, Uppsala, Sweden (author)
  • Ulfstedt, MikaelOlink Prote AB, Uppsala, Sweden (author)
  • Johansson, MattiasInt Agcy Res Canc IARC WHO, Genom Epidemiol Branch, Lyon, France (author)
  • Sokolov, Aleksandr V.Uppsala universitet,Funktionell farmakologi och neurovetenskap(Swepub:uu)aleso209 (author)
  • Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi och neurovetenskap(Swepub:uu)helgschi (author)
  • Hall, PerKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; Södersjukhuset, Dept Oncol, Stockholm, Sweden (author)
  • Schwenk, Jochen M.KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1h7wtme (author)
  • Czene, KamilaKarolinska Institutet (author)
  • Hedman, Åsa K.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; Pfizer Worldwide Res Dev & Med, Stockholm, Sweden (author)
  • Pfizer Worldwide Res Dev & Med, Stockholm, SwedenKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; Hlth & Med Univ, Inst Clin Res & Syst Med, Potsdam, Germany (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Nature14:12041-1723

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