Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training

QC 20240102
Exercise training has tremendous systemic tissue-specific health benefits, but the molecular adaptations to long-term exercise training are not completely understood. We investigated the skeletal muscle proteome of highly endurance-trained, strength-trained, and untrained individuals and performed exercise- and sex-specific analyses. Of the 6,000+ proteins identified, >650 were differentially expressed in endurance-trained individuals compared with controls. Strikingly, 92% of the shared proteins with higher expression in both the male and female endurance groups were known mitochondrial. In contrast to the findings in endurance-trained individuals, minimal differences were found in strength-trained individuals and between females and males. Lastly, a co-expression network and comparative literature analysis revealed key proteins and pathways related to the health benefits of exercise, which were primarily related to differences in mitochondrial proteins. This network is available as an interactive database resource where investigators can correlate clinical data with global gene and protein expression data for hypothesis generation.

Arif, MuhammadKTH,Systembiologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1vvaean (författare)
Reitzner, Stefan M.Karolinska Institutet (författare)
Perez, SeanDepartment of Biology, Pomona College, Claremont, CA 91711, USA (författare)
Lindholm, Maléne E.Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA (författare)
Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London WC2R 2LS, UK(Swepub:kth)u1t8kmr6 (författare)
Daub, CarstenDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm 171 77, Sweden; Science for Life Laboratory, Solna 171 65, Sweden (författare)
Sundberg, Carl JohanKarolinska Institutet (författare)
Chapman, Mark A.Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden; Department of Integrated Engineering, University of San Diego, San Diego, CA 92110, USA (författare)
Karolinska InstitutetSystembiologi (creator_code:org_t)

Av författaren/redakt...: Emanuelsson, Eri ...; Arif, Muhammad; Reitzner, Stefan ...; Perez, Sean; Lindholm, Maléne ...; Mardinoglu, Adil; visa fler...; Daub, Carsten; Sundberg, Carl J ...; Chapman, Mark A.; visa färre...

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