WFRF:(Wang Ziyu)
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- Yu, Meijuan (author)
3D local structure around Zn in Kti11p as a representative Zn-(Cys)4 motif as obtained by MXAN
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- Elsevier BV,2008
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-34300
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-34300URI
- https://doi.org/10.1016/j.bbrc.2008.06.116DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20110601
- Zinc is an important component of many proteins that play key roles in transcription, translation, and catalysis. Kti11p, DESR1, both belonging to a protein family characterized by a CSL zinc finger domain, and the co-catalytic zinc-protein PML containing a Zn2+ binding domain called RING or C3HC4 finger are all structurally determined by NMR although the zinc sites are silent to this spectroscopical method. The comparison of X-ray absorption near-edge spectroscopy (XANES) data for the three proteins demonstrates that fingerprints effect is a reliable method for a primary characterization of ligand species. Ab initio full MS Calculations performed by MAN are applied to obtain chemical and stereo structural information around the Zn ion in Kti11p. For the first time this high-spatial resolution technique confirms the formation of a stable Zn tetrahedral configuration with four sulfur ligands, and returns extremely accurate bond angle information between ligands.
Subject headings and genre
- TEKNIK OCH TEKNOLOGIER Industriell bioteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Industrial Biotechnology hsv//eng
- zinc motif
- Kti11p
- EXAFS
- XANES
- fingerprints
- MXAN
- Bioengineering
- Bioteknik
Added entries (persons, corporate bodies, meetings, titles ...)
- Yang, Feifei (author)
- Chu, Wangsheng (author)
- Wang, Yu (author)
- Zhao, Haifeng (author)
- Gao, BinKTH,Teoretisk kemi(Swepub:kth)u1jvwzpv (author)
- Zhao, Wei (author)
- Sun, Jianping (author)
- Wu, Fangming (author)
- Zhang, Xiaowei (author)
- Shi, Yunyu (author)
- Wu, Ziyu (author)
- KTHTeoretisk kemi (creator_code:org_t)
Related titles
- In:Biochemical and Biophysical Research Communications - BBRC: Elsevier BV374:1, s. 28-320006-291X1090-2104
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- Zhao, Wei
- Sun, Jianping
- Wu, Fangming
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- Shi, Yunyu
- Wu, Ziyu
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- Royal Institute of Technology
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