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Xist ribonucleoprot...
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Dou, Diana R.Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
(author)
Xist ribonucleoproteins promote female sex-biased autoimmunity
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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Elsevier BV,2024
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-343195
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-343195URI
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https://doi.org/10.1016/j.cell.2023.12.037DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20240209
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Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) is expressed only in females to randomly inactivate one of the two X chromosomes to achieve gene dosage compensation. Here, we show that the Xist ribonucleoprotein (RNP) complex comprising numerous autoantigenic components is an important driver of sex-biased autoimmunity. Inducible transgenic expression of a non-silencing form of Xist in male mice introduced Xist RNP complexes and sufficed to produce autoantibodies. Male SJL/J mice expressing transgenic Xist developed more severe multi-organ pathology in a pristane-induced lupus model than wild-type males. Xist expression in males reprogrammed T and B cell populations and chromatin states to more resemble wild-type females. Human patients with autoimmune diseases displayed significant autoantibodies to multiple components of XIST RNP. Thus, a sex-specific lncRNA scaffolds ubiquitous RNP components to drive sex-biased immunity.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Zhao, YandingCenter for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
(author)
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Belk, Julia A.Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
(author)
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Zhao, YangCenter for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
(author)
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Casey, Kerriann M.Department of Comparative Medicine, Stanford University, Stanford, CA, USA
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Chen, Derek C.Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
(author)
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Li, RuiCenter for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
(author)
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Yu, BingfeiCenter for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
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Srinivasan, SuhasCenter for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
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Abe, Brian T.Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
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Kraft, KaterinaCenter for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
(author)
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Hellström, CeciliaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1doy1fn
(author)
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Sjöberg, RonaldKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1j1wpi6
(author)
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Chang, SarahDepartment of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
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Feng, AllanDepartment of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
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Goldman, Daniel W.Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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Shah, Ami A.Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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Petri, MichelleDepartment of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
(author)
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Chung, Lorinda S.Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
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Fiorentino, David F.Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA
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Käller Lundberg, EmmaKTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Departments of Bioengineering and Pathology, Stanford University, Stanford, CA, USA(Swepub:kth)u12bylj1
(author)
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Wutz, AntonDepartment of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
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Utz, Paul J.Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA
(author)
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Chang, Howard Y.Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
(author)
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Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USADepartment of Comparative Medicine, Stanford University, Stanford, CA, USA
(creator_code:org_t)
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In:Cell: Elsevier BV187:3, s. 16-7330092-86741097-4172
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Dou, Diana R.
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Zhao, Yanding
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Belk, Julia A.
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Zhao, Yang
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Casey, Kerriann ...
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Chen, Derek C.
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Li, Rui
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Yu, Bingfei
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Srinivasan, Suha ...
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Abe, Brian T.
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Kraft, Katerina
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Hellström, Cecil ...
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Sjöberg, Ronald
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Chang, Sarah
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Feng, Allan
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Goldman, Daniel ...
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Shah, Ami A.
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Petri, Michelle
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Chung, Lorinda S ...
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Fiorentino, Davi ...
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Käller Lundberg, ...
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Wutz, Anton
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Utz, Paul J.
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Chang, Howard Y.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Cell
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Royal Institute of Technology