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Sökning: id:"swepub:oai:DiVA.org:kth-344022" > A human stomach cel...

  • Öling, S.Department of Clinical Medicine, Translational Vascular Research, The Arctic University of Norway, 9019, Tromsø, Norway,Arctic Univ Norway, Dept Clin Med, Translat Vasc Res, N-9019 Tromso, Norway. (författare)

A human stomach cell type transcriptome atlas

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Springer Nature,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-344022
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-344022URI
  • https://doi.org/10.1186/s12915-024-01812-5DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524333URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154912618URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20240301
  • Background: The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointestinal tract, provides an acidic environment that contributes to microbial defence and facilitates the activity of secreted digestive enzymes to process food and nutrients into chyme. In contrast to other sections of the gastrointestinal tract, detailed descriptions of cell type gene enrichment profiles in the stomach are absent from the major single-cell sequencing-based atlases. Results: Here, we use an integrative correlation analysis method to predict human stomach cell type transcriptome signatures using unfractionated stomach RNAseq data from 359 individuals. We profile parietal, chief, gastric mucous, gastric enteroendocrine, mitotic, endothelial, fibroblast, macrophage, neutrophil, T-cell, and plasma cells, identifying over 1600 cell type-enriched genes. Conclusions: We uncover the cell type expression profile of several non-coding genes strongly associated with the progression of gastric cancer and, using a sex-based subset analysis, uncover a panel of male-only chief cell-enriched genes. This study provides a roadmap to further understand human stomach biology.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Struck, E.Department of Clinical Medicine, Translational Vascular Research, The Arctic University of Norway, 9019, Tromsø, Norway,Arctic Univ Norway, Dept Clin Med, Translat Vasc Res, N-9019 Tromso, Norway. (författare)
  • Noreen-Thorsen, M.Department of Clinical Medicine, Translational Vascular Research, The Arctic University of Norway, 9019, Tromsø, Norway,Arctic Univ Norway, Dept Clin Med, Translat Vasc Res, N-9019 Tromso, Norway. (författare)
  • Zwahlen, MartinKTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Royal Inst Technol KTH, Dept Prot Sci, Sci Life Lab, S-17121 Stockholm, Sweden.(Swepub:kth)u1fcjpxe (författare)
  • von Feilitzen, KalleKTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Royal Inst Technol KTH, Dept Prot Sci, Sci Life Lab, S-17121 Stockholm, Sweden.(Swepub:kth)u1dbmi38 (författare)
  • Odeberg, Jacob,Professor,1963-KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Department of Clinical Medicine, Translational Vascular Research, The Arctic University of Norway, 9019, Tromsø, Norway; The University Hospital of North Norway (UNN), 9019, Tromsø, Norway; Department of Haematology, Coagulation Unit, Karolinska University Hospital, 171 76, Stockholm, Sweden,Arctic Univ Norway, Dept Clin Med, Translat Vasc Res, N-9019 Tromso, Norway.;Royal Inst Technol KTH, Dept Prot Sci, Sci Life Lab, S-17121 Stockholm, Sweden.;Univ Hosp North Norway UNN, N-9019 Tromso, Norway.;Karolinska Univ Hosp, Dept Haematol, Coagulat Unit, S-17176 Stockholm, Sweden.(Swepub:kth)u1e4yljo (författare)
  • Pontén, FredrikUppsala universitet,Cancerprecisionsmedicin(Swepub:uu)fredpont (författare)
  • Lindskog, CeciliaUppsala universitet,Cancerprecisionsmedicin(Swepub:uu)cecli129 (författare)
  • Uhlén, MathiasKTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Royal Inst Technol KTH, Dept Prot Sci, Sci Life Lab, S-17121 Stockholm, Sweden.(Swepub:kth)u1dulvmw (författare)
  • Dusart, PhilipKTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Clinical Chemistry and Blood Coagulation Research, Department of Molecular Medicine and Surgery, Karolinska Institute, 171 76, Stockholm, Sweden; Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital, 171 76, Stockholm, Sweden,Royal Inst Technol KTH, Dept Prot Sci, Sci Life Lab, S-17121 Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Clin Chem & Blood Coagulat Res, S-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, S-17176 Stockholm, Sweden.(Swepub:kth)u13mq3yk (författare)
  • Butler, Lynn M.KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Department of Clinical Medicine, Translational Vascular Research, The Arctic University of Norway, 9019, Tromsø, Norway; Science for Life Laboratory, Department of Protein Science, Royal Institute of Technology (KTH), 171 21, Stockholm, Sweden; Clinical Chemistry and Blood Coagulation Research, Department of Molecular Medicine and Surgery, Karolinska Institute, 171 76, Stockholm, Sweden; Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital, 171 76, Stockholm, Sweden,Arctic Univ Norway, Dept Clin Med, Translat Vasc Res, N-9019 Tromso, Norway.;Royal Inst Technol KTH, Dept Prot Sci, Sci Life Lab, S-17121 Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Clin Chem & Blood Coagulat Res, S-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, S-17176 Stockholm, Sweden.(Swepub:kth)u1tkjrxa (författare)
  • Department of Clinical Medicine, Translational Vascular Research, The Arctic University of Norway, 9019, Tromsø, NorwayArctic Univ Norway, Dept Clin Med, Translat Vasc Res, N-9019 Tromso, Norway. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Biology: Springer Nature22:11741-7007

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