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Sökning: L773:0016 6480 > (2020-2024) > Mechanistic study o...

Mechanistic study of transcription factor Sox18 during heart development

Liang, Jianxin (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Ul Hassan, Imtiaz (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Yee Cheung, Man (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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Feng, Lei (författare)
School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China; Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, China
Lin, Yi jyun (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Long, Qi (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Wang, Chengdong (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Ding, Yuyue (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Wang, Ziqing (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Zhang, Yuan (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Li, Yulong (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Guo, Donghao (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Guo, Xiaofang (författare)
School of Life Sciences, Jinan University, Guangzhou, China
Chi Bun Wong, Thomas (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Kaleem Samma, Muhammad (författare)
Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, China
Rong, Zixin (författare)
KTH,Genteknologi
Qi, Xufeng (författare)
School of Life Sciences, Jinan University, Guangzhou, China
Cai, Dongqing (författare)
School of Life Sciences, Jinan University, Guangzhou, China
Ngai, Sai Ming (författare)
School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China
Zhao, Hui (författare)
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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 (creator_code:org_t)
Elsevier BV, 2024
2024
Engelska.
Ingår i: General and Comparative Endocrinology. - : Elsevier BV. - 0016-6480 .- 1095-6840. ; 350
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Heart development is a delicate and complex process regulated by coordination of various signaling pathways. In this study, we investigated the role of sox18 in heart development by modulating Wnt/β-Catenin signaling pathways. Our spatiotemporal expression analysis revealed that sox18 is mainly expressed in the heart, branchial arch, pharyngeal arch, spinal cord, and intersegmental vessels at the tailbud stage of Xenopus tropicalis embryo. Overexpression of sox18 in the X. tropicalis embryos causes heart edema, while loss-of-function of sox18 can change the signal of developmental heart marker gata4 at different stages, suggesting that sox18 plays an essential role in the development of the heart. Knockdown of SOX18 in human umbilical vein endothelial cells suggests a link between Sox18 and β-CATENIN, a key regulator of the Wnt signaling pathway. Sox18 negatively regulates islet1 and tbx3, the downstream factors of Wnt/β-Catenin signaling, during the linear heart tube formation and the heart looping stage. Taken together, our findings highlight the crucial role of Sox18 in the development of the heart via inhibiting Wnt/β-Catenin signaling.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Heart development
Sox18
Transcriptional factor
Wnt signaling pathway
Xenopus

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