Angiogenesis in bone tissue engineering via ceramic scaffolds: A review of concepts and recent advancements

Abdollahi, FarnooshDepartment of Dentistry, Kashan University of Medical Science, Kashan, Iran (author)

QC 20240321
Due to organ donor shortages, long transplant waitlists, and the complications/limitations associated with auto and allotransplantation, biomaterials and tissue-engineered models are gaining attention as feasible alternatives for replacing and reconstructing damaged organs and tissues. Among various tissue engineering applications, bone tissue engineering has become a promising strategy to replace or repair damaged bone. We aimed to provide an overview of bioactive ceramic scaffolds in bone tissue engineering, focusing on angiogenesis and the effect of different biofunctionalization strategies. Different routes to angiogenesis, including chemical induction through signaling molecules immobilized covalently or non-covalently, in situ secretion of angiogenic growth factors, and the degradation of inorganic scaffolds, are described. Physical induction mechanisms are also discussed, followed by a review of methods for fabricating bioactive ceramic scaffolds via microfabrication methods, such as photolithography and 3D printing. Finally, the strengths and weaknesses of the commonly used methodologies and future directions are discussed.

Saghatchi, MahshidSchool of Metallurgy & Materials Engineering, Iran University of Science and Technology, Tehran, Iran (author)
Paryab, AmirhoseinDepartment of Materials Science & Engineering, Sharif University of Technology, Tehran, Iran (author)
Malek Khachatourian, AdrineDepartment of Materials Science & Engineering, Sharif University of Technology, Tehran, Iran (author)
Stephens, Emma D.Department of Biomedical Engineering, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada, 2500 University Drive NW (author)
Toprak, Muhammet,1973-KTH,Biomedicinsk fysik och röntgenfysik(Swepub:kth)u1u3m5a2 (author)
Badv, MaryamDepartment of Biomedical Engineering, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada, 2500 University Drive NW; Libin Cardiovascular Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada, 3330 Hospital Drive NW (author)
Department of Dentistry, Kashan University of Medical Science, Kashan, IranSchool of Metallurgy & Materials Engineering, Iran University of Science and Technology, Tehran, Iran (creator_code:org_t)

By the author/editor: Abdollahi, Farno ...; Saghatchi, Mahsh ...; Paryab, Amirhose ...; Malek Khachatour ...; Stephens, Emma D ...; Toprak, Muhammet ...; show more...; Badv, Maryam; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Biomaterials Sci ...

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