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WFRF:(Czarnewski Paulo 1991 )
 

Sökning: WFRF:(Czarnewski Paulo 1991 ) > High-parametric pro...

High-parametric protein maps reveal the spatial organization in early-developing human lung

Sariyar, Sanem (författare)
KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Emma Lundberg
Sountoulidis, Alex (författare)
Science for; Laboratory, Solna, SwedenDepartment of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
Hansen, Jan N. (författare)
KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Department of Bioengineering, Stanford University, Stanford, CA, USA
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Marco Salas, Sergio (författare)
Science for Life Laboratory, Solna, Sweden; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Mardamshina, Mariya (författare)
KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik
Martinez Casals, Ana (författare)
KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Department of Bioengineering, Stanford University, Stanford, CA, USA
Ballllosera Navarro, Frederic (författare)
KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Department of Bioengineering, Stanford University, Stanford, CA, USA
Andrusivova, Zaneta (författare)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Li, Xiaofei (författare)
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Czarnewski, Paulo, 1991- (författare)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Lundeberg, Joakim (författare)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Linnarsson, Sten (författare)
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Nilsson, Mats (författare)
Science for Life Laboratory, Solna, Sweden; Department of Biochemistry and Biophysisc, Stockholm University, Stockholm, Sweden
Sundström, Erik (författare)
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Samakovlis, Christos (författare)
Science for Life Laboratory, Solna, Sweden; Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; Molecular Pneumology, Cardiopulmonary Institute, Justus Liebig University, Giessen, Germany
Käller Lundberg, Emma (författare)
KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA
Ayoglu, Burcu (författare)
KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik
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 (creator_code:org_t)
Engelska.
Relaterad länk:
https://kth.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Annan publikation (övrigt vetenskapligt/konstnärligt)
Abstract Ämnesord
Stäng  
  • The respiratory system, encompassing the lungs, trachea, and vasculature, is essential for terrestrial life. Although recent research has illuminated aspects of lung development, such as cell lineage origins and their molecular drivers, much of our knowledge is still based on animal models, or is deduced from transcriptome analyses. In this study, conducted within the Human Developmental Cell Atlas (HDCA) initiative, we describe the spatiotemporal organization of lung during the first trimester of human gestation in situ and at protein level. We used high-parametric tissue imaging on human lung samples, aged 6 to 13 post-conception weeks, using a 30-plex antibody panel. Our approach yielded over 2 million individual lung cells across five developmental timepoints, with an in-depth analysis of nearly 1 million cells. We present a spatially resolved cell type composition of the developing human lung, with a particular emphasis on their proliferative states, spatial arrangement traits, and their temporal evolution throughout lung development. We also offer new insights into the emerging patterns of immune cells during lung development. To the best of our knowledge, this study is the most extensive protein-level examination of the developing human lung. The generated dataset is a valuable resource for further research into the developmental roots of human respiratory health and disease.

Ämnesord

NATURVETENSKAP  -- Biologi -- Utvecklingsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Developmental Biology (hsv//eng)

Nyckelord

Biotechnology
Bioteknologi

Publikations- och innehållstyp

vet (ämneskategori)
ovr (ämneskategori)

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