WFRF:(Zhang Zixuan)
Sökning: WFRF:(Zhang Zixuan) > Zeolitic imidazolat...
Zeolitic imidazolate framework-90 loaded with methylprednisolone sodium succinate effectively reduces hypertrophic scar in vivo
-
- Xu, Xiaoxiang (författare)
- Wuhan Univ, Zhongnan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wuhan 430071, Peoples R China.
-
- Liu, Jun (författare)
- Wuhan Univ, Zhongnan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wuhan 430071, Peoples R China.;China Three Gorges Univ, Yichang Cent Peoples Hosp, Coll Clin Med Sci 1, Dept Otorhinolaryngol Head & Neck Surg, Yichang 430003, Peoples R China.
-
- Xiao, Zixuan (författare)
- Shaanxi Normal Univ, Coll Life Sci, China Sweden Int Joint Res Ctr Brain Dis, Natl Engn Lab Resource Developing Endangered Chin, Xian 710119, Peoples R China.
- visa fler...
- visa färre...
- Wuhan Univ, Zhongnan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wuhan 430071, Peoples R China Wuhan Univ, Zhongnan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wuhan 430071, Peoples R China.;China Three Gorges Univ, Yichang Cent Peoples Hosp, Coll Clin Med Sci 1, Dept Otorhinolaryngol Head & Neck Surg, Yichang 430003, Peoples R China. (creator_code:org_t)
- Royal Society of Chemistry (RSC), 2024
- 2024
- Engelska.
- Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 16:13, s. 6708-6719
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Hypertrophic scar (HS) is characterized by an abnormal fibroblast-myofibroblast transformation; non-apoptosis of fibroblasts; and redundant expression of TGF-beta 1, VEGF, alpha-SMA, and collagen I/III. An HS affects patients' physical and psychological quality of life, leading to joint dysfunction and skin cancer. However, there is currently no satisfactory drug to treat this disorder. In this study, we constructed methylprednisolone sodium succinate (MPSS) encapsulated ZIF-90 (MPSS@ZIF-90) for the effective treatment of an HS. The encapsulation of MPSS in ZIF-90 can achieve the controllable drug release of MPSS and prolong its effective treatment time. MPSS@ZIF-90 enhanced the apoptosis of human hypertrophic scar fibroblasts and downregulated the overexpression of TGF-beta 1, VEGF, alpha-SMA, and collagen I/III both in vitro and in vivo. The instant injection of MPSS@ZIF-90 effectively intervened with the formation of the HS after 28 days. On the contrary, MPSS@ZIF-90 greatly reduced the HS with two injections and 14 days of treatment after the HS was formed. This work provides evidence of effective intervention in the formation of an HS and the therapeutic effectiveness of MPSS@ZIF-90 with short treatment periods in vivo. It suggests that MPSS@ZIF-90 can be used as a biomedical option in the treatment of skin wounds and may reveal the potential molecular basis for promising future antifibrotic agents against scarring.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta mer i SwePub
- Av författaren/redakt...
- Xu, Xiaoxiang
- Liu, Jun
- Xiao, Zixuan
- Li, Shuang
- Zhang, Ya
- Song, Peng
- visa fler...
- Lin, Kun
- Zhang, Lei
- Zheng, Haoquan
- Zhou, Yuye
- Chen, Xiong
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- Artiklar i publikationen
- Nanoscale
- Av lärosätet
- Kungliga Tekniska Högskolan
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
