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Transcriptome Analysis Reveals Distinct Patterns Between the Invasive and Noninvasive Pituitary Neuroendocrine Tumors
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- Jotanovic, Jelena (författare)
- Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds V 20, S-75185 Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, S-75185 Uppsala, Sweden.,Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University , 75185 Uppsala , Sweden;Department of Clinical Pathology, Uppsala University Hospital , 75185 Uppsala , Sweden
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- Abdellah, Tebani (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KNormandie Univ, Dept Metab Biochem, INSERM U1245, UNIROUEN,CHU Rouen, F-76000 Rouen, France.,Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology , 17121 Solna, Stockholm , Sweden;Department of Metabolic Biochemistry, UNIROUEN, INSERM U1245, CHU Rouen, Normandie University , 76000 Rouen , France
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- Hekmati, Neda (författare)
- Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds V 20, S-75185 Uppsala, Sweden.,Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University , 75185 Uppsala , Sweden
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- Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds V 20, S-75185 Uppsala, Sweden;Uppsala Univ Hosp, Dept Clin Pathol, S-75185 Uppsala, Sweden. Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University , 75185 Uppsala , Sweden;Department of Clinical Pathology, Uppsala University Hospital , 75185 Uppsala , Sweden (creator_code:org_t)
- The Endocrine Society, 2024
- 2024
- Engelska.
- Ingår i: Journal of the Endocrine Society. - : The Endocrine Society. - 2472-1972. ; 8:5
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Although most pituitary neuroendocrine tumors (PitNETs)/pituitary adenomas remain intrasellar, a significant proportion of tumors show parasellar invasive growth and 6% to 8% infiltrate the bone structures, thus affecting the prognosis. There is an unmet need to identify novel markers that can predict the parasellar growth of PitNETs. Furthermore, mechanisms that regulate bone invasiveness of PitNETs and factors related to tumor vascularization are largely unknown.We used genome-wide mRNA analysis in a cohort of 77 patients with PitNETs of different types to explore the differences in gene expression patterns between invasive and noninvasive tumors with respect to the parasellar growth and regarding the rare phenomenon of bone invasiveness. Additionally, we studied the genes correlated to the contrast enhancement quotient, a novel radiological parameter of tumor vascularization.Most of the genes differentially expressed related to the parasellar growth were genes involved in tumor invasiveness. Differentially expressed genes associated with bone invasiveness are involved in NF-kappa B pathway and antitumoral immune response. Lack of clear clustering regarding the parasellar and bone invasiveness may be explained by the influence of the cell lineage-related genes in this heterogeneous cohort of PitNETs.Our transcriptomics analysis revealed differences in the molecular fingerprints between invasive, including bone invasive, and noninvasive PitNETs, although without clear clustering. The contrast enhancement quotient emerged as a radiological parameter of tumor vascularization, correlating with several angiogenesis-related genes. Several of the top genes related to the PitNET invasiveness and vascularization have potential prognostic and therapeutic application requiring further research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- PitNET
- transcriptomics
- RNA-sequencing
- pituitary adenoma
- pathology
- invasiveness
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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