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Sökning: WFRF:(Küster K.) > (2020-2024) > Decrypting lysine d...

  • Chang, Yun ChienChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria (författare)

Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-347048
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-347048URI
  • https://doi.org/10.1016/j.celrep.2024.114272DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20240703
  • Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PTCL), and multiple myeloma, but many aspects of their cellular mechanism of action (MoA) and substantial toxicity are not well understood. To shed more light on how KDACis elicit cellular responses, we systematically measured dose-dependent changes in acetylation, phosphorylation, and protein expression in response to 21 clinical and pre-clinical KDACis. The resulting 862,000 dose-response curves revealed, for instance, limited cellular specificity of histone deacetylase (HDAC) 1, 2, 3, and 6 inhibitors; strong cross-talk between acetylation and phosphorylation pathways; localization of most drug-responsive acetylation sites to intrinsically disordered regions (IDRs); an underappreciated role of acetylation in protein structure; and a shift in EP300 protein abundance between the cytoplasm and the nucleus. This comprehensive dataset serves as a resource for the investigation of the molecular mechanisms underlying KDACi action in cells and can be interactively explored online in ProteomicsDB.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gnann, ChristianKTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1338pp0 (författare)
  • Steimbach, Raphael R.Cancer Drug Development, German Cancer Research Center (DKFZ), Heidelberg, Baden-Wurttemberg, Germany, Baden-Württemberg; Biosciences Faculty, Heidelberg University, Heidelberg, Baden-Wurttemberg, Germany, Baden-Württemberg (författare)
  • Bayer, Florian P.Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria (författare)
  • Lechner, SeverinChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria (författare)
  • Sakhteman, AmirhosseinChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria (författare)
  • Abele, MiriamChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria (författare)
  • Zecha, JanaChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria (författare)
  • Trendel, JakobChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria (författare)
  • The, MatthewChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria (författare)
  • Käller Lundberg, EmmaKTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA(Swepub:kth)u12bylj1 (författare)
  • Miller, Aubry K.Cancer Drug Development, German Cancer Research Center (DKFZ), Heidelberg, Baden-Wurttemberg, Germany, Baden-Württemberg; German Cancer Consortium (DKTK), Heidelberg, Baden-Wurttemberg, Germany, Baden-Württemberg (författare)
  • Kuster, BernhardChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, Bavaria; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, Baden-Wurttemberg, Germany, Baden-Württemberg (författare)
  • Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Bavaria, Germany, BavariaCellulär och klinisk proteomik (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cell Reports: Elsevier BV43:62211-1247

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