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Guided Mode Induced...
Guided Mode Induced Surface Phase Mutation for Enhanced SPR Biosensor with Dual-Parameters Interrogation
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- Liu, Zhenchao (författare)
- Centre for Optical and Electromagnetic Research College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China; Taizhou Hospital, Zhejiang University, Taizhou, 318000, P. R. China
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- Guo, Tingbiao (författare)
- Centre for Optical and Electromagnetic Research College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China
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- Tan, Qin (författare)
- Centre for Optical and Electromagnetic Research College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China
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- Fan, Houxin (författare)
- Centre for Optical and Electromagnetic Research College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China
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- He, Sailing (författare)
- KTH,Elektromagnetism och fusionsfysik,Taizhou Hospital, Zhejiang University, Taizhou, 318000, P. R. China
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Centre for Optical and Electromagnetic Research College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310058, P R. China; Taizhou Hospital, Zhejiang University, Taizhou, 318000, P. R. China Centre for Optical and Electromagnetic Research College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China (creator_code:org_t)
- Wiley, 2023
- 2023
- Engelska.
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Ingår i: Advanced Materials Interfaces. - : Wiley. - 2196-7350. ; 10:34
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Ongoing research on the sensitivity and integration of refractive index-based biosensors has resulted in significant advancements. Here, the study presents an enhanced surface plasmon resonance biosensor that integrates imaging technology and features dual-parameter interrogation (intensity and phase) with guided mode coupling. By depositing a silica-waveguide-layer on a metal-layer, two-mode coupling is established to generate a high Q resonance and induce a phase mutation. The sensing performance experiment demonstrated a phase sensing sensitivity of 1.1 × 105 degree RIU−1, Q-value of the resonant peak up to 314, and figure of merit of 300 RIU−1, superior to most standard plasmonic sensors. An in-line phase-polarization modulation scheme combined with imaging technology is proposed to extract the resonant phase carrying refractive index information. Additionally, a pair-prism module is designed to optimize the sensing system configuration. Meanwhile, dual-parameters interrogation including the intensity and phase are demonstrated, which offers potential for complementary and multi-sensing fusion applications. The intensity interrogation also shows a considerable sensitivity of 7.2 × 104 a.u. RIU−1. Furthermore, it is combined with microfluidic chip to detect of alpha-synuclein protein closely related to Parkinson's disease, and the limit of detection can reach 300 pg mL−1 level, which indicated a considerable potential for high-throughput diagnosis application.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- alpha-synuclein
- guided mode coupling
- imaging biosensors
- phase-polarization modulation
- surface plasmon resonance (SPR)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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