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Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

Masarapu, Yuvarani (författare)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
Cekanaviciute, Egle (författare)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field
Andrusivova, Zaneta (författare)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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Westholm, Jakub O. (författare)
National Bioinformatics Infrastructure Sweden, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Stockholm, Sweden
Björklund, Åsa (författare)
Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Fallegger, Robin (författare)
Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany
Badia-i-Mompel, Pau (författare)
Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany; GSK, Cellzome, Heidelberg, Germany
Boyko, Valery (författare)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field; Bionetics, Yorktown, VA, USA
Vasisht, Shubha (författare)
Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA
Saravia-Butler, Amanda (författare)
KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field
Gebre, Samrawit (författare)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field
Lázár, Enikő (författare)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
Graziano, Marta (författare)
Department of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden
Frapard, Solene (författare)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
Hinshaw, Robert G. (författare)
NASA Postdoctoral Program - Oak Ridge Associated Universities, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field
Bergmann, Olaf (författare)
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden; Pharmacology and Toxicology, Department of Pharmacology and Toxicology University Medical Center Goettingen, Goettingen, Germany
Taylor, Deanne M. (författare)
Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA
Wallace, Douglas C. (författare)
Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and Department of Pediatrics, Division of Human Genetics, The University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA
Sylvén, Christer (författare)
Department of Medicine, Karolinska Institute, Huddinge, Sweden
Meletis, Konstantinos (författare)
Department of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden
Saez-Rodriguez, Julio (författare)
Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany
Galazka, Jonathan M. (författare)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field
Costes, Sylvain V. (författare)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field
Giacomello, Stefania (författare)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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 (creator_code:org_t)
Springer Nature, 2024
2024
Engelska.
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate the impact of spaceflight on the mouse brain in female mice. Our comparative analysis between ground control and spaceflight-exposed animals revealed significant alterations in essential brain processes including neurogenesis, synaptogenesis and synaptic transmission, particularly affecting the cortex, hippocampus, striatum and neuroendocrine structures. Additionally, we observed astrocyte activation and signs of immune dysfunction. At the pathway level, some spaceflight-induced changes in the brain exhibit similarities with neurodegenerative disorders, marked by oxidative stress and protein misfolding. Our integrated spatial multiomics approach serves as a stepping stone towards understanding spaceflight-induced CNS impairments at the level of individual brain regions and cell types, and provides a basis for comparison in future spaceflight studies. For broader scientific impact, all datasets from this study are available through an interactive data portal, as well as the National Aeronautics and Space Administration (NASA) Open Science Data Repository (OSDR).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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