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  • Masarapu, YuvaraniKTH,Genteknologi,Science for Life Laboratory, SciLifeLab (författare)

Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Springer Nature,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-348766
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-348766URI
  • https://doi.org/10.1038/s41467-024-48916-8DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20240628
  • Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate the impact of spaceflight on the mouse brain in female mice. Our comparative analysis between ground control and spaceflight-exposed animals revealed significant alterations in essential brain processes including neurogenesis, synaptogenesis and synaptic transmission, particularly affecting the cortex, hippocampus, striatum and neuroendocrine structures. Additionally, we observed astrocyte activation and signs of immune dysfunction. At the pathway level, some spaceflight-induced changes in the brain exhibit similarities with neurodegenerative disorders, marked by oxidative stress and protein misfolding. Our integrated spatial multiomics approach serves as a stepping stone towards understanding spaceflight-induced CNS impairments at the level of individual brain regions and cell types, and provides a basis for comparison in future spaceflight studies. For broader scientific impact, all datasets from this study are available through an interactive data portal, as well as the National Aeronautics and Space Administration (NASA) Open Science Data Repository (OSDR).

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Cekanaviciute, EgleSpace Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field (författare)
  • Andrusivova, ZanetaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u147zn3v (författare)
  • Westholm, Jakub O.National Bioinformatics Infrastructure Sweden, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Stockholm, Sweden (författare)
  • Björklund, ÅsaDepartment of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden (författare)
  • Fallegger, RobinHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany (författare)
  • Badia-i-Mompel, PauHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany; GSK, Cellzome, Heidelberg, Germany (författare)
  • Boyko, ValerySpace Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field; Bionetics, Yorktown, VA, USA (författare)
  • Vasisht, ShubhaDepartment of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA (författare)
  • Saravia-Butler, AmandaKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field (författare)
  • Gebre, SamrawitSpace Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field (författare)
  • Lázár, EnikőKTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden(Swepub:kth)u124lih7 (författare)
  • Graziano, MartaDepartment of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden (författare)
  • Frapard, SoleneKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1myanv3 (författare)
  • Hinshaw, Robert G.NASA Postdoctoral Program - Oak Ridge Associated Universities, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field (författare)
  • Bergmann, OlafDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden; Pharmacology and Toxicology, Department of Pharmacology and Toxicology University Medical Center Goettingen, Goettingen, Germany (författare)
  • Taylor, Deanne M.Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA (författare)
  • Wallace, Douglas C.Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and Department of Pediatrics, Division of Human Genetics, The University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA (författare)
  • Sylvén, ChristerDepartment of Medicine, Karolinska Institute, Huddinge, Sweden (författare)
  • Meletis, KonstantinosDepartment of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden (författare)
  • Saez-Rodriguez, JulioHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany (författare)
  • Galazka, Jonathan M.Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field (författare)
  • Costes, Sylvain V.Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field (författare)
  • Giacomello, StefaniaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1j2tb2i (författare)
  • KTHGenteknologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Communications: Springer Nature15:12041-1723

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