Contrast-enhanced dual-energy subtraction imaging using electronic spectrum-splitting and multi-prism x-ray lenses

Proceedings of the Society of Photo-Optical Instrumentation Engineers,0277-786X ;6913

QC 20210121
Dual-energy subtraction imaging (DES) is a method to improve the detectability of contrast agents over a lumpy background. Two images, acquired at x-ray energies above and below an absorption edge of the agent material, are logarithmically subtracted, resulting in suppression of the signal from the tissue background and a relative enhancement of the signal from the agent. Although promising, DES is still not widely used in clinical practice. One reason may be the need for two distinctly separated x-ray spectra that are still close to the absorption edge, realized through dual exposures which may introduce motion unsharpness. In this study, electronic spectrum-splitting with a silicon-strip detector is theoretically and experimentally investigated for a mammography model with iodinated contrast agent. Comparisons are made to absorption imaging and a near-ideal detector using a signal-to-noise ratio that includes both statistical and structural noise. Similar to previous studies, heavy absorption filtration was needed to narrow the spectra at the expense of a large reduction in x-ray flux. Therefore, potential improvements using a chromatic multi-prism x-ray lens (MPL) for filtering were evaluated theoretically. The MPL offers a narrow tunable spectrum, and we show that the image quality can be improved compared to conventional filtering methods.

Cederström, BjörnKTH,Medicinsk bildfysik(Swepub:kth)u1oerth9 (författare)
Lundqvist, Mats (författare)
Ribbing, CarolinaUppsala universitet,Fasta tillståndets elektronik(Swepub:uu)cri24390 (författare)
Åslund, Magnus (författare)
Diekmann, FelixCharité - Univ. Hospital (Germany) (författare)
Nishikawa, RobertUniv. of Chicago (United States) (författare)
Danielsson, MatsKTH,Medicinsk bildfysik(Swepub:kth)u1m3qe0f (författare)
KTHMedicinsk bildfysik (creator_code:org_t)

Ingår i:Medical Imaging 2008 - Physics of Medical ImagingSan Diego, CA, USA : SPIE, s. 91310-913109780819470973

Av författaren/redakt...: Fredenberg, Erik ...; Cederström, Björ ...; Lundqvist, Mats; Ribbing, Carolin ...; Åslund, Magnus; Diekmann, Felix; visa fler...; Nishikawa, Rober ...; Danielsson, Mats; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...; och Biomedicinsk lab ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.