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Assigning significa...
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Käll, Lukas,1969-Department of Genome Sciences, University of Washington, Seattle
(författare)
Assigning significance to peptides identified by tandem mass spectrometry using decoy databases
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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2007-12-08
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American Chemical Society (ACS),2008
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-48854
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-48854URI
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https://doi.org/10.1021/pr700600nDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20111124
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Automated methods for assigning peptides to observed tandem mass spectra typically return a list of peptide-spectrum matches, ranked according to an arbitrary score. In this article, we describe methods for converting these arbitrary scores into more useful statistical significance measures. These methods employ a decoy sequence database as a model of the null hypothesis, and use false discovery rate (FDR) analysis to correct for multiple testing. We first describe a simple FDR inference method and then describe how estimating and taking into account the percentage of incorrectly identified spectra in the entire data set can lead to increased statistical power.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Storey, John D.
(författare)
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MacCoss, Michael J.
(författare)
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Noble, William Stafford
(författare)
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Department of Genome Sciences, University of Washington, Seattle
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Proteome Research: American Chemical Society (ACS)7:1, s. 29-341535-38931535-3907
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