The local field potential reflects surplus spike synchrony

Sökning: L773:1047 3211 > The local field pot...

QC 20120130
While oscillations of the local field potential (LFP) are commonly attributed to the synchronization of neuronal firing rate on the same time scale, their relationship to coincident spiking in the millisecond range is unknown. Here, we present experimental evidence to reconcile the notions of synchrony at the level of spiking and at the mesoscopic scale. We demonstrate that only in time intervals of significant spike synchrony that cannot be explained on the basis of firing rates, coincident spikes are better phase locked to the LFP than predicted by the locking of the individual spikes. This effect is enhanced in periods of large LFP amplitudes. A quantitative model explains the LFP dynamics by the orchestrated spiking activity in neuronal groups that contribute the observed surplus synchrony. From the correlation analysis, we infer that neurons participate in different constellations but contribute only a fraction of their spikes to temporally precise spike configurations. This finding provides direct evidence for the hypothesized relation that precise spike synchrony constitutes a major temporally and spatially organized component of the LFP.

NATURVETENSKAP Data- och informationsvetenskap hsv//swe
NATURAL SCIENCES Computer and Information Sciences hsv//eng
CAT VISUAL-CORTEX; PRIMATE MOTOR CORTEX; CEREBRAL-CORTEX; SENSORIMOTOR CORTEX; CORTICAL NETWORKS; UNITARY EVENTS; WORKING-MEMORY; NEURONAL SYNCHRONIZATION; COHERENT OSCILLATIONS; PREFRONTAL CORTEX

Roux, S (författare)
Lindén, HenrikNorwegian Univ Life Sci, Dept Math Sci & Technol(Swepub:kth)u1atpjhg (författare)
Diesmann, M (författare)
Riehle, A (författare)
Grün, S (författare)
Norwegian Univ Life Sci, Dept Math Sci & Technol (creator_code:org_t)

Ingår i:Cerebral Cortex: Oxford University Press (OUP)21:12, s. 2681-26951047-32111460-2199

Av författaren/redakt...: Denker, M; Roux, S; Lindén, Henrik; Diesmann, M; Riehle, A; Grün, S

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.