Microalbuminuria and Left Ventricular Functions in Type 2 Diabetes: A Quantitative Assessment by Stress Echocardiography in the Myocardial Doppler in Diabetes (MYDID) Study III

Microalbuminuria and Left Ventricular Functions in Type 2 Diabetes : A Quantitative Assessment by Stress Echocardiography in the Myocardial Doppler in Diabetes (MYDID) Study III

QC 20100709
Background. Left ventricular (LV) function might be altered in type 2 diabetes (DM) and microalbuminuria (MA) may accentuate the abnormalities. We sought to investigate whether additional LV dysfunction could be unmasked using tissue Doppler (TVE)-enhanced dobutamine stress echocardiography (TVE-DSE) in patients with DM+MA. Methods. Twenty seven DM subjects with MA, (DM+MA), 31 DM subjects without MA (DM-MA), and 13 Controls were evaluated using TVE-DSE. LV basal peak systolic (PSV), early (E') and late (A') diastolic velocities (cm/sec) at rest and peak stress were post-processed. LV filling pressure was assessed using E/E'ratio. Results. PSV and E'velocity at peak stress in the respective three groups were 13.7±1.0, 10.1±1.1, 10.0±1.2 for PSV; and 10.0±1.6, 5.0±1.4, 4.8±1.4 for E' (p < 0.001 for controls vs. both groups). E/E' at rest was 7.9±0.7 in the controls, 10.8±2.4 in DM-MA, and 11.0±2.2 in DM+MA (p < 0.01 Controls vs. both the DM groups). Conclusions. Patients with DM+MA do not have additional LV regional systolic and diastolic dysfunctions compared with DM-MA, as revealed by TVE-DSE, when controlled for glycemia levels, lipids, and treatment strategies.

Brodin, Lars-ÅkeKarolinska Institutet,KTH,Medicinsk teknik(Swepub:kth)u1jq9s27 (author)
Nowak, J.Karolinska Institutet (author)
Arvind, S. R.Karolinska Institutet (author)
Ramesh, S. S.BMJ Heart Center, Bangalore, India (author)
Netyö, A.Karolinska Institute, Department of Clinical Physiology, Karolinska University Hospital at Huddinge, Stockholm, Sweden (author)
Prasad, K.Y.M.BMJ Heart Center, Bangalore, India (author)
Saha, S.Karolinska Institute, Department of Clinical Physiology, Karolinska University Hospital at Huddinge, Stockholm, Sweden (author)
BMJ Heart Center, Bangalore, IndiaMedicinsk teknik (creator_code:org_t)

In:International Journal of Cardiology: Informa UK Limited41:6, s. 363-3690167-52731874-1754
In:Scandinavian Cardiovascular Journal: Informa UK Limited41:6, s. 363-3691401-74311651-2006

By the author/editor: Govind, Satish C ...; Brodin, Lars-Åke; Nowak, J.; Arvind, S. R.; Ramesh, S. S.; Netyö, A.; show more...; Prasad, K.Y.M.; Saha, S.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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