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- Larsson, RikardKTH,Kemi (author)
Catalytic Self-Screening of Cholinesterase Substrates from a Dynamic Combinatorial Thioester Library
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- Wiley,2004
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-8265
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-8265URI
- https://doi.org/10.1002/anie.200454165DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- QC 20100818
- Simply the best: Dynamic combinatorial chemistry coupled to enzyme catalysis was used to identify enzyme substrates in a library constructed from a series of thioesters and thiols by transesterification. The library was directly coupled to the catalytic action of acetylcholinesterase, which selectively hydrolyzed the best substrate candidates (see schematic representation). The process allowed rapid identification of discrete substrates.
Subject headings and genre
- NATURVETENSKAP Kemi Organisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Organic Chemistry hsv//eng
- combinatorial chemistry; enzyme catalysis hydrolysis; proteomics; transesterification
- Organic chemistry
- Organisk kemi
Added entries (persons, corporate bodies, meetings, titles ...)
- Pei, ZhichaoKTH,Kemi(Swepub:kth)u1g7ykh0 (author)
- Ramström, OlofKTH,Kemi(Swepub:kth)u1aj7snf (author)
- KTHKemi (creator_code:org_t)
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- In:Angewandte Chemie International Edition: Wiley43:28, s. 3716-37181433-78511521-3773
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